Purinergic Signaling Polarization Control

**Molecular Mechanism and Rationale** The purinergic signaling pathway represents a fundamental regulatory system controlling astrocyte phenotypic polarization through the opposing actions of P2Y1 and P2X7 receptors. P2Y1 (P2RY1) is a Gq/G11-coupled metabotropic receptor that responds to ADP with high affinity (EC50 ~100 nM), triggering phospholipase C-β activation and subsequent IP3-mediated calcium release from endoplasmic reticulum stores. This generates sustained, oscillatory calcium waves ...