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Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma.

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paper Created: By: unknown Quality: 50% ✓ SciDEX ID: paper-35256934
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Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma.
Du D, Liu C, Qin M, Zhang X, Xi T, Yuan S, Hao H, Xiong J
Acta pharmaceutica Sinica. B PubMed DOI
Abstract

Hepatocellular carcinoma (HCC) is an aggressive human cancer with increasing incidence worldwide. Multiple efforts have been made to explore pharmaceutical therapies to treat HCC, such as targeted tyrosine kinase inhibitors, immune based therapies and combination of chemotherapy. However, limitations exist in current strategies including chemoresistance for instance. Tumor initiation and progression is driven by reprogramming of metabolism, in particular during HCC development. Recently, metabol...

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