Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancement

**Molecular Mechanism and Rationale** Grid cells in layer II of the entorhinal cortex represent one of the brain's most metabolically demanding neuronal populations due to their continuous spatial computation and persistent theta-frequency firing patterns. These specialized neurons maintain hexagonal firing fields that require sustained high-frequency oscillations at 4-12 Hz, creating extraordinary metabolic stress that may contribute to their selective vulnerability in neurodegenerative diseas...