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βIII-Tubulin Gene Regulation in Health and Disease.
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ID: paper-35573698
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βIII-Tubulin Gene Regulation in Health and Disease.
Duly AMP, Kao FCL, Teo WS, Kavallaris M
Abstract
Microtubule proteins form a dynamic component of the cytoskeleton, and play key roles in cellular processes, such as vesicular transport, cell motility and mitosis. Expression of microtubule proteins are often dysregulated in cancer. In particular, the microtubule protein βIII-tubulin, encoded by the TUBB3 gene, is aberrantly expressed in a range of epithelial tumours and is associated with drug resistance and aggressive disease. In normal cells, TUBB3 expression is tightly restricted, and is fo...
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