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Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
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ID: paper-35750033
📄 Paper Details
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
["Tcw J", "Qian L", "Pipalia N", "Chao M", "Liang S", "Shi Y", "Jain B", "Bertelsen S", "Kapoor M", "Marcora E"]
Abstract
The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's disease (AD), on human brain cellular function remains unclear. Here, we investigated the effects of APOE4 on brain cell types derived from population and isogenic human induced pluripotent stem cells, post-mortem brain, and APOE targeted replacement mice. Population and isogenic models demonstrate that APOE4 local haplotype, rather than a single risk allele, contributes to risk. Global transcriptomic an...
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