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Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation.
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ID: paper-41376284
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Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation.
Xie XY, Wang L, Xie SQ, Zhou GF, Wen QX, Ma YL, Zhang QL, Yan XX, Luo B, Chen J, Song L, Chen X, Li CL, Pan QL, Liu Y, Xiang XJ, Chen GJ
Abstract
FURIN cleaves a subset of proproteins into functional mature fragments. Evidence suggests that FURIN is involved in brain development and the associated diseases, whereas the potential mechanisms remain incompletely understood. Here, we report that cerebral FURIN-deficient mice exhibit cognitive decline and neurodegeneration. Lipid droplets (LDs) that are preferentially accumulated in astrocytes correlate with an increase of the LD markers PLIN2 and PLIN3, and conversely a decreased level of aut...
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