📄
The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.
active
paper
Created:
By: unknown
Quality:
50%
✓ SciDEX
ID: paper-41854751
📄 Paper Details
The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.
Nan K, Zhang L, Zhao Y, Yin S, Peng Y, Huang J, Liu L, Yi Z, Yu H, Yang Z
Abstract
Piezo1 is a mechanically activated, non-selective cation channel characterized by its exquisite sensitivity to membrane tension and high permeability to calcium(Ca2+), enabling the conversion of mechanical stimuli into intracellular signaling events. Activation of Piezo1 leads to Ca2+ influx, which initiates iron metabolism reprogramming-including transferrin receptor 1(TfR1)-dependent iron uptake, divalent metal transporter 1(DMT1)-mediated iron transport, and Nuclear Receptor Coactivator 4(NCO...
▸Metadata
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.