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Constitutive expression of CX3CR1-BAC-Cre introduces minimal off-target effects in microglia.
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ID: paper-41924777
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Constitutive expression of CX3CR1-BAC-Cre introduces minimal off-target effects in microglia.
Mroue-Ruiz FH, Desai B, Garvin MM, Shehu JH, Kamau F, Kar U, Bolton JL
Abstract
CX3CR1-Cre mouse lines have produced important advancements in our understanding of microglial biology. Recent studies have demonstrated the adverse effects of tamoxifen-induced CX3CR1-Cre expression during development, which may include changes in microglial density, phenotype, and DNA damage, as well as anxiety-like behavior. However, the unintended effects of constitutive CX3CR1-BAC-Cre expression remain unexplored. Here, we characterized the effects of CX3CR1-BAC-Cre expression on microglia ...
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