Microglial Purinergic Reprogramming

**Molecular Mechanism and Rationale** The P2Y12 receptor (encoded by P2RY12) represents a critical nexus in microglial purinergic signaling that governs neuroinflammatory responses and tau pathology propagation in neurodegenerative diseases. P2Y12 is a Gi/Go-coupled metabotropic purinergic receptor that serves as the primary ADP sensor on microglial cells, functioning as a molecular switch between homeostatic surveillance and pathological activation states. Under physiological conditions, P2Y12...