Fig. 4: PA load in peripheral organs and brain regions. a Bacterial growth in lung and...

PA load in peripheral organs and brain regions. a Bacterial growth in lung and spleen (CFUs per mg of tissue) and brain (in CSF; CFU per μL) obtained from infected animals (OD 600 0.3) and controls after intratracheal administration of PA at 24 h, 7-days and 1-month post-infection. b Representative confocal micrograph showing ( b ) lung and ( c ) spleen sections obtained from GFP-labelled PA infected animals at 24 h post-infection (OD 600 0.3) and controls. PA is labelled in green and nuclei (DAPI) in blue. d–g Representative confocal micrographs of ( d ) cortical sections, ( e ) choroid plexus ( f ) hippocampus and ( g ) isolated capillaries showing the lack of distribution of PA (GFP-labelled PA) in the brain of infected mice at 24 h post-infection and controls. Lectin (red) was used to label the blood vessels in tissue sections and claudin-5 or ZO-1 (red) to label isolated capillaries. DAPI (blue) was used to stain the nuclei

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