🖼
Fig. 4: Inhibition of NF-κB pathway in vivo restores brain endothelial Wnt/β-catenin sig...
active
paper figure
Created: 2026-04-16T11:31:41
By: paper_figures_pipeline
Quality:
95%
🔗 External
ID: paper-fig-39427196-4
Fig. 4Figure 4
Inhibition of NF-κB pathway in vivo restores brain endothelial Wnt/β-catenin signaling and attenuates LPS-induced BBB leakage and neuroinflammation. A , Schematic illustration of experimental design. The NF-κB pathway inhibitor BAY 11-7085 (5 mg/kg) or vehicle control (DMSO) was intraperitoneally (i.p.) injected to mice at 30 min after LPS or saline injection. B , Mortality rate of mice at 24 h following vehicle ( n = 10 mice), LPS + vehicle ( n = 14 mice), or LPS + BAY 11-7085 ( n = 15 mice) treatment. C , Body weight change of the mice at 24 h after vehicle ( n = 10 mice), LPS + vehicle ( n = 9 mice), or LPS + BAY 11-7085 ( n = 10 mice) treatment. D , Co-immunofluorescence staining of NF-κB p65 and CD31 in the brain cortex and its quantifications. NF-κB p65 signal in endothelial cells was selectively quantified. E , Co-immunofluorescence staining of VCAM1 and CD31 in the brain cortex and its quantifications. F , Co-immunofluorescence staining of LEF1 and CD31 in the brain
▸Metadata
| doi | |
| pmcid | PMC11491032 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11491032/bin/12974_2024_3261_Fig4_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-16T11:31:41.927139'} |
| caption | Inhibition of NF-κB pathway in vivo restores brain endothelial Wnt/β-catenin signaling and attenuates LPS-induced BBB leakage and neuroinflammation. A , Schematic illustration of experimental design. |
| paper_id | 39427196 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11491032/bin/12974_2024_3261_Fig4_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 4 |
| figure_number | 4 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.