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Fig. 4: The inhibition of NETs formation reduced BBB permeability in SAE mice by allevia...
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Created: 2026-04-16T11:31:44
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Fig. 4Figure 4
The inhibition of NETs formation reduced BBB permeability in SAE mice by alleviating TJs disruption. A The BWC was measured. Quantification of the FS extravasation in the hippocampus ( B ) and the global brain tissue ( C ) (n = 6). D Representative images showing the extravasation of FS. E Expression levels of TJs (ZO-1, Occludin, Claudin-5) proteins in the hippocampus were detected by Western blot (n = 6). F Expression levels of TJ proteins were quantified and normalized to GAPDH levels (n = 6). Double labeling shows colocalization of Occludin ( G ) and ZO-1 ( I ) with ECs (CD31) in the CA1 region of the hippocampus (40x, n = 6). Quantification of the fluorescence intensity of Occludin ( H ) and ZO-1 ( J ) in the hippocampus. NETs: Neutrophil extracellular traps; CLP: Cecal Ligation and Puncture; SAE: Sepsis-associated encephalopathy; ECs: endothelial cells; BBB: Blood–brain barrier; TJs: Tight junctions; BWC: Brain water content; FS: Fluorescein sodium. (ns: no significance,
▸Metadata
| doi | |
| pmcid | PMC11917101 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig4_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-16T11:31:44.217701'} |
| caption | The inhibition of NETs formation reduced BBB permeability in SAE mice by alleviating TJs disruption. A The BWC was measured. Quantification of the FS extravasation in the hippocampus ( B ) and the g |
| paper_id | 40102948 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig4_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 4 |
| figure_number | 4 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
1
0 supporting
0 contradicting
0 neutral
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