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Fig. 1: Dynamic microglial activation programs and signaling networks in Alzheimer’s dis...
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Created: 2026-04-11T11:42:25
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ID: paper-fig-41569436-1
Fig. 1Figure 1
Dynamic microglial activation programs and signaling networks in Alzheimer’s disease (AD). Under physiological conditions, microglia exist in a state of homeostatic surveillance, which is essential for maintaining synapses and monitoring the immune system. In response to amyloid-β accumulation, tau pathology, and cellular stress, microglia undergo dynamic transcriptional and functional reprogramming rather than fixed polarization. Pro-inflammatory microglial activation programs, driven by Toll-like receptors (TLR), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and Janus kinase (JAK)-signal transducer and activator of transcription (STAT) (JAK/STAT) signaling, promote cytokine release, oxidative stress, and neuronal injury when persistently engaged. Conversely, repair-associated and phagocytic microglial programs regulated by AMP-activated protein kinase (AMPK), phosphoinositide 3-kinase/ protein kinase B (PI3K/AKT), peroxisome proliferator-activated receptor g
▸Metadata
| doi | 10.1007/s10571-026-01671-4 |
| pmid | 41569436 |
| pmcid | PMC12891327 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12891327/bin/10571_2026_1671_Fig1_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-11T18:42:25.464335'} |
| caption | Dynamic microglial activation programs and signaling networks in Alzheimer’s disease (AD). Under physiological conditions, microglia exist in a state of homeostatic surveillance, which is essential fo |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12891327/bin/10571_2026_1671_Fig1_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 1 |
| figure_number | 1 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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