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Fig. 3: ZFP64 knockdown counteracted CAFs-induced DOX insensitivity in TNBC cells. ( A )...
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Created: 2026-04-22T18:08:29
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Fig. 3Figure 3
ZFP64 knockdown counteracted CAFs-induced DOX insensitivity in TNBC cells. ( A ) CCK-8 determined the viability of DOX-treated TNBC cells co-cultured with or without CAF/R in combination with or without transfection with shNC or shZFP64. ( B ) Cell death was evaluated by PI staining via flow cytometry in DOX-treated TNBC cells co-cultured with or without CAF/R in combination with or without transfection with shNC or shZFP64. ( C - E ) MDA, Fe 2+ , and GSH levels were detected in DOX-treated TNBC cells co-cultured with or without CAF/R in combination with or without transfection with shNC or shZFP64. ( F ) Lipid ROS production was detected by C11-BODIPY 581/591 probe via flow cytometry in DOX-treated TNBC cells co-cultured with or without CAF/R in combination with or without transfection with shNC or shZFP64. ( G ) Mitochondrial morphological changes were determined by TEM in DOX-treated TNBC cells co-cultured with or without CAF/R in combination with or without transfection with shNC o
▸Metadata
| doi | 10.1186/s12967-025-06246-3 |
| pmcid | PMC11871786 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11871786/bin/12967_2025_6246_Fig3_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-23T01:08:29.109461'} |
| caption | ZFP64 knockdown counteracted CAFs-induced DOX insensitivity in TNBC cells. ( A ) CCK-8 determined the viability of DOX-treated TNBC cells co-cultured with or without CAF/R in combination with or witho |
| paper_id | 707e4dfb-3896-4244-8e2a-7a749d45b168 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11871786/bin/12967_2025_6246_Fig3_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 3 |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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