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Fig. 3: Deficiency of GAS6/AXL signal exacerbated BBB breakdown during JEV infection. WT...
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Created: 2026-04-22T18:14:25
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Fig. 3Figure 3
Deficiency of GAS6/AXL signal exacerbated BBB breakdown during JEV infection. WT and AXL −/− mice were infected with JEV 10 6 PFU via foot pad. A . Viral copies in each brain sample were tested by qPCR. Data were normalized to β-actin and the relative change was calculated based on the viral level of WT-d3-1. At 3 dpi, WT n = 3, AXL −/− n = 3; at 5 dpi, WT n = 4, AXL −/− n = 3. Data are shown as mean ± SD. B . The JEV E protein in the brain was detected by WB. At 3 dpi, WT n = 3, AXL −/− n = 3; at 5 dpi, WT n = 4, AXL −/− n = 3. C . Qualitative detection of BBB permeability via EB staining at 3 and 5 dpi. D . Quantitative assay of BBB permeability using NaF extravasation. NaF leakage was calculated based on the fluorescence ratio in the brain to blood. PBS: WT n = 5, AXL −/− n = 3; 3 dpi: WT n = 12, AXL −/− n = 12; 5 dpi: WT n = 4, AXL −/− n = 3. The data represent the mean ± SD E . Representative images show the co-localisation of endothelial cells (CD31, r
▸Metadata
| doi | 10.1186/s12974-024-03225-1 |
| pmcid | PMC11411859 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11411859/bin/12974_2024_3225_Fig3_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-23T01:14:25.011557'} |
| caption | Deficiency of GAS6/AXL signal exacerbated BBB breakdown during JEV infection. WT and AXL −/− mice were infected with JEV 10 6 PFU via foot pad. A . Viral copies in each brain sample were tested by |
| paper_id | f224acb2-095b-423e-980a-e4cb8c8f61c8 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11411859/bin/12974_2024_3225_Fig3_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 3 |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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