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Fig. 7 — Prolonged anesthesia induces neuroinflammation and complement-mediated microglia
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Created: 2026-04-21T18:29:40
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Fig. 7Figure 7
Microglial depletion rescued cognitive dysfunction and ameliorated anxiety-like behaviors in SIN rats. A The schedule of the second experiment. We used chow with PLX3397 to feed rats for 21 days, depleting the microglial population. B iba1 (green) positive microglia were sharply depleted in the hippocampus after PLX3397 treatment. Scale bar = 200 μm. C PLX3397 treatment effectively eliminated microglial marker-iba1 expression in the hippocampus. D Statistical chart of iba1 expression between both groups ( n = 4 per group). E, F Microglial depletion rescued cognitive dysfunction of SIN rats ( n = 7 per group). In MWM, microglial depletion increased the number and time of entering the platform quadrant of SIN rats. G, H Microglial depletion ameliorated anxiety-like behaviors of SIN rats ( n = 7 per group). In the OPF test, microglial depletion increased the time and number of entering the central zone of SIN rats. I, J Microglial depletion ameliorated anxiety-like behavi
▸Metadata
| pmid | paper-133bd96a1c04 |
| caption | Microglial depletion rescued cognitive dysfunction and ameliorated anxiety-like behaviors in SIN rats. A The schedule of the second experiment. We used chow with PLX3397 to feed rats for 21 days, de |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC9814183/bin/12916_2022_2705_Fig7_HTML.jpg |
| paper_title | Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors. |
| figure_label | Fig. 7 |
| figure_number | 7 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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