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Fig. 8 — Potent and specific MTH1 inhibitors targeting gastric cancer.
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Created: 2026-04-21T18:29:40
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Fig. 8Figure 8
Proposed mechanisms for MI-743 induced cell death in gastric cancer cells MGC-803 and HGC-27 through targeting MTH1. In gastric cancer cells MGC-803 and HGC-27(left), increased ROS convert dGTP and dATP to 8-oxo-dGTP and 2-OH-dATP, respectively. The overexpressed MTH1 hydrolyzes the oxidized triphosphates into the corresponding 8-oxo-dGMP and 2-OH-dAMP, in order to prevent their incorporation into double strand DNA and further maintain cancer cell survival. However, under the treatment of compound MI-743(right), the enhanced activity of MTH1 in cancer cells is inhibited. The oxidized nucleotides (8-oxo-dGTP and 2-OH-dATP) will be incorporated into DNA, which further causes double strand DNA damage and finally induces cell death
▸Metadata
| pmid | paper-18d2a490986a |
| caption | Proposed mechanisms for MI-743 induced cell death in gastric cancer cells MGC-803 and HGC-27 through targeting MTH1. In gastric cancer cells MGC-803 and HGC-27(left), increased ROS convert dGTP and dA |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC6547740/bin/41419_2019_1665_Fig8_HTML.jpg |
| paper_title | Potent and specific MTH1 inhibitors targeting gastric cancer. |
| figure_label | Fig. 8 |
| figure_number | 8 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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