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Figure 2 — Small nucleoli are a cellular hallmark of longevity.
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Created: 2026-04-21T18:29:40
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ID: paper-fig-paper-5839e7d0e39b-2
Figure 2Figure 2
Nucleolar size inversely correlates with longevity. ( a ) eat-2(ad465) animals have smaller nucleoli while ncl-1(e1942) and eat-2;ncl-1 animals possess larger nucleoli compared to N2. (20 worms imaged per replicate, 3 independent biological replicates) ( b ) Nucleolar size is reduced on bacterial food reduction with a corresponding increase in lifespan. ( P <0.0001, log-rank test). ( c , d ) eat-2(ad465) , TOR RNAi, isp-1(qm150) , glp-1(e2141) and daf-2(e1370) animals possess smaller nucleoli while daf-2;daf-16 have nucleoli similar to N2 in the hypodermis and pharyngeal muscle (Error bars represent mean±s.d.) ( e , f ) Schematic illustrating the experiment, which shows that longer-lived worms exhibit small nucleoli and vice versa. (The graph depicts mean and s.d. Pearson correlation coefficient R 2 =0.93 is calculated using the entire data set, the line equation is y =−0.1483x+6.9148). Scale bar represents 5 μm. * P <0.05, ** P <0.01, *** P <0.001, **** P <0.0001, NS,
▸Metadata
| pmid | paper-5839e7d0e39b |
| caption | Nucleolar size inversely correlates with longevity. ( a ) eat-2(ad465) animals have smaller nucleoli while ncl-1(e1942) and eat-2;ncl-1 animals possess larger nucleoli compared to N2. (20 worms |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC5582349/bin/ncomms16083-f2.jpg |
| paper_title | Small nucleoli are a cellular hallmark of longevity. |
| figure_label | Figure 2 |
| figure_number | 2 |
| _schema_version | 1 |
| source_strategy | pmc_api |
📊 Evidence Profile
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