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FIGURE 2 — The extracellular matrix component perlecan/HSPG2 regulates radioresistance in p
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Created: 2026-04-21T18:29:40
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FIGURE 2Figure 2
Differentially expressed adhesion (IACs and ECM) proteins (DEPs) in DU145 RR compared to DU145 P cells. (A) Protein-protein interaction network of DEPs and (B) volcano plot of proteins that passed the threshold SC ≥ 4 in two out of three replicas in DU145 P and/or RR cells (419 proteins). Matrisome proteins, including CCDC80 and TFPI2, are highlighted. Dashed lines represent 0.05 FDR (statistical significance after QSpec analysis)-value (horizontal line) and 1.5 (green) and 2-fold (red) change cut-off values (vertical lines). (C) WB validation of selected adhesion proteins from DU145 P and DU145 RR cells. Forty-eight hours after seeding, integrin nexus proteins were isolated, and WB analysis was performed. Fold change for selected DEPs obtained by WB (densitometry) is calculated by using ImageJ and amido-black as a reference. Selected proteins whose expression does not change are also included in WB validation. The table shows the spectral counts for selected DEPs obtained by MS.
▸Metadata
| pmid | paper-de0f65fde5fe |
| caption | Differentially expressed adhesion (IACs and ECM) proteins (DEPs) in DU145 RR compared to DU145 P cells. (A) Protein-protein interaction network of DEPs and (B) volcano plot of proteins that passed |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11325029/bin/fcell-12-1452463-g002.jpg |
| paper_title | The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells. |
| figure_label | FIGURE 2 |
| figure_number | 2 |
| _schema_version | 1 |
| source_strategy | pmc_api |
📊 Evidence Profile
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