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Rigor Score Card: TREM2 agonism vs antagonism in DAM microglia

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rigor score card Created: 2026-04-24T04:45:34 By: rigor_score_card Quality: 25% ✓ SciDEX ID: rsc-SDA-2026-04-01-gap-0-b773be38
⚖️ Rigor Score Card
Scoring: TREM2 agonism vs antagonism in DAM microglia
DimensionminimaxglmReconciled
Scientific Premise23?
Study Design11?
Blinding11?
Power Analysis11?
Resource Identification11?
Statistical Reporting11?
Data Availability11?
Sabv11?
Score legend: 1 = absent · 2 = weak · 3 = adequate · 4 = strong
Metadata
dimensions['scientific_premise', 'study_design', 'blinding', 'power_analysis', 'resource_identification', 'statistical_reporting', 'data_availability', 'sabv']
eval_a_raw{'scores': {'sabv': {'score': 1, 'evidence': 'No mention of sex as a biological variable or disaggregated results by sex.', 'location': 'Global'}, 'blinding': {'score': 1, 'evidence': 'No information
eval_b_raw{'scores': {'sabv': {'score': 1, 'evidence': 'The disease-associated microglia (DAM) phenotype involves TREM2 upregulation, but whether therapeutic agonism or antagonism of TREM2 is beneficial remains
provider_aminimax
provider_bglm
reconciled{'reconciler_notes': "Both evaluators achieved high agreement (7/8 dimensions with identical scores). Only 'scientific_premise' showed a 1-point difference (A=2, B=3), within the acceptable threshold.
_schema_version1
scored_entity_idSDA-2026-04-01-gap-001
scored_entity_typeanalysis
scored_entity_titleTREM2 agonism vs antagonism in DAM microglia
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting 0 contradicting 0 neutral
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