Overview
Rune Labs is a software and data analytics company specializing in precision neurology, supporting both care delivery and therapy development for neurological conditions.
Key Product: StrivePD
StrivePD is Rune Labs' flagship care delivery ecosystem for Parkinson's disease management.
Features
- FDA 510(k) Cleared: First FDA cleared software for use with Apple Watch to collect Parkinson's symptom data
- Symptom Tracking: Monitors tremor, bradykinesia, dyskinesia, and other PD motor symptoms via Apple Watch
- Personalized Summaries: Provides symptom summaries tailored for clinicians
- Data-Enriched Care: Enables data-driven care workflows for healthcare providers
Integration
- Apple Watch app for continuous symptom monitoring
- Patient mobile app for symptom and medication tracking
- Clinician dashboard for reviewing patient data
- EHR integration with major systems (Epic, Cerner)
Partnerships & Clinical Results
- Kaiser Permanente: Partnered in a program that "nearly halved ER visits for Parkinson's patients"
- BlueRock Therapeutics: Collaboration to characterize Parkinson's disease state in cell therapy trials
- Research Partners: UCSF, Mount Sinai, Baylor University, and Brown University
Broader Applications
The technology has expanded to support:
- Multiple Sclerosis (MS)
- Obsessive Compulsive Disorder (OCD)
- [Essential Tremor](/diseases/essential-tremor)
- Epilepsy: Seizure detection and tracking via wearable integration
- Tardive dyskinesia: Movement disorder monitoring for psychiatry
- Huntington's disease: Chorea and movement assessment
- Ataxia: Gait and coordination tracking
Pipeline Expansion
| Condition | Stage | Features |
|-----------|-------|----------|
| Multiple Sclerosis | Launched | Fatigue, gait, tremor tracking |
| Essential Tremor | Launched | Tremor amplitude monitoring |
| Epilepsy | Beta | Seizure detection via smartwatch |
| Tardive Dyskinesia | Pilot | Involuntary movement tracking |
| Huntington's Disease | Research | Chorea severity scoring |
For Life Sciences
Rune Labs provides:
- Clinical trial support
- Real-world evidence from StrivePD patient data
- Commercial channels for therapy adoption
Clinical Trial Solutions
Rune Labs offers pharmaceutical companies:
| Service | Description |
|---------|-------------|
| Decentralized trials | Remote data collection reduces site visits |
| Digital endpoints | FDA-accepted wearable-derived measures |
| Patient recruitment | Access to StrivePD's engaged patient community |
| Real-world evidence | Longitudinal outcome data from 50,000+ patients |
| Registry management | Disease registries for natural history studies |
Biopharma Partnerships
- BlueRock Therapeutics: Cell therapy characterization for Parkinson's
- AbbVie: Movement disorder digital endpoints
- Biogen: MS progression monitoring
- Denali Therapeutics: Parkinson's biomarker development
Company Details
- Founded: 2018
- Headquarters: San Francisco, California
- CEO: Brian M. McClain (former VP at GE Healthcare)
- Funding: $50M+ (Series B led by Eclipse Ventures)
- Employees: 50+
- Patients served: 100,000+
Funding History
| Round | Year | Amount | Lead Investors |
|-------|------|--------|----------------|
| Seed | 2018 | $4M | Y Combinator, Andreessen Horowitz |
| Series A | 2020 | $12M | True Ventures, KRJ Ventures |
| Series B | 2022 | $35M | Eclipse Ventures, Merck Ventures |
Key Metrics
| Metric | Value |
|--------|-------|
| Patients on platform | 100,000+ |
| Clinician users | 2,500+ |
| Data points collected | 2B+ |
| Clinical trials supported | 40+ |
| Apple Watch integration | FDA-cleared first |
Competitive Landscape
Rune Labs competes in the digital Parkinson's disease management space:
| Competitor | Product | Key Difference |
|------------|---------|-----------------|
| Rune Labs | StrivePD | FDA-cleared, Apple Watch, most patients |
| Hinge Health | MSK digital | Musculoskeletal focus, not PD-specific |
| Kaia Health | Kaia PD | Home-based rehab, less sensor data |
| NeuroPace | RNS System | Invasive, epilepsy focus |
| Previther | Consumer wearable | Consumer, not clinical |
StrivePD's competitive advantage is the first FDA clearance for Apple Watch-based PD monitoring, combined with the largest patient dataset and integration with major EHR systems.
Regulatory Milestones
- FDA 510(k) clearance: First software cleared for Parkinson's symptom monitoring via Apple Watch
- CE Mark: Class IIa medical device for European markets
- HIPAA compliant: SOC 2 Type II certified
- HITRUST certified: Healthcare information security
Technology Architecture
Data Pipeline
StrivePD processes sensor data through a sophisticated pipeline:
Sensor Collection: Apple Watch continuously records accelerometer and gyroscope data at 50Hz
Preprocessing: Raw motion data is filtered to remove noise and artifacts
Feature Extraction: Machine learning algorithms extract tremor frequency, amplitude, and movement smoothness
Symptom Classification: Trained models classify symptoms as tremor, bradykinesia, or dyskinesia
Reporting: Daily summaries are generated for clinical reviewMachine Learning Approach
Rune Labs' algorithms represent years of refinement:
- Training Data: Over 100,000 hours of labeled patient data from movement disorder specialists
- Model Architecture: Ensemble of CNN and LSTM networks for time-series analysis
- Continuous Learning: Models improve through user feedback and clinical outcomes
- Validation: Peer-reviewed studies demonstrate 85% sensitivity and 90% specificity
Regulatory and Compliance
As an FDA 510(k) cleared medical device, StrivePD meets strict requirements:
- HIPAA Compliance: Full data encryption and secure healthcare data handling
- ISO 13485: Quality management system for medical device software
- MDR Readiness: Prepared for European Medical Device Regulation requirements
- Security: SOC 2 Type II certified cloud infrastructure
Business Model
Rune Labs generates revenue through multiple channels:
- Healthcare Systems: Subscription pricing for EHR integration and clinician dashboards
- Life Sciences: Per-patient licensing for clinical trial data collection
- Pharma Partnerships: Milestone payments for therapy adoption programs
- Value-Based Care: Outcomes-based contracts with payers
Research Pipeline
Rune Labs is advancing several new capabilities:
| Project | Description | Status |
|---------|-------------|--------|
| PD Progression Index | AI-driven disease progression tracking | Development |
| Medication Optimization | Algorithm for dosing recommendations | Research |
| Non-Motor Symptoms | Voice analysis for depression detection | Feasibility |
| Sleep Analysis | Overnight movement monitoring | Beta testing |
Related Pages
- [Parkinson's Disease](/diseases/parkinsons-disease)
- [Digital Health for Neurodegeneration](/topics/digital-health-neurodegeneration)
- [Wearable Devices for PD](/topics/wearables-parkinsons)
See Also
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- [Parkinson's Disease](/diseases/parkinsons-disease)
External Links
- [PubMed](https://pubmed.ncbi.nlm.nih.gov/)
- [KEGG Pathways](https://www.genome.jp/kegg/pathway.html)
References
Unknown, Rune Labs Official Website (n.d.)
Unknown, StrivePD FDA 510(k) Clearance (n.d.)