Dataset Overview

Introduction

This page provides an overview of datasets available for neurodegenerative disease research, including genomics, transcriptomics, proteomics, imaging, and clinical data. [@adni2024]

Major Data Resources

Genomics Databases

| Dataset | Disease | Samples | Access | [@ppmi2024]
|---------|---------|---------|--------| [@ampad2024]
| AMP-AD | AD | 2,000+ | NIAGADS |
| AMP-PD | PD | 10,000+ | AMP-PD |
| Target ALS | ALS | 1,000+ | Target ALS |
| ALSGene | ALS | 15,000+ | Project MinE |

Imaging Databases

| Dataset | Disease | Modalities | Access |
|---------|---------|------------|--------|
| ADNI | AD | MRI, PET | LONI |
| AIBL | AD | MRI, PET | Application |
| PPMI | PD | MRI, DAT | LONI |
| OASIS | AD | MRI | Public |
| DIAN | AD | MRI, PET | DIAN |
| GENIE | AD | MRI, PET, Genetics | LONI |

Clinical Databases

| Dataset | Disease | Patients | Access |
|---------|---------|----------|--------|
| NACC | AD, PD, FTD | 40,000+ | NACC |
| CLINICALtrials.gov | All | 50,000+ | Public |
| CurePSP | PSP, CBD | 5,000+ | Application |

Data Types

Genomic Data

• Whole genome sequencing: Rare variant discovery
• Exome sequencing: Protein-coding variants
• GWAS: Common variant associations
• RNA-seq: Gene expression

Proteomic Data

• Mass spectrometry: Protein quantification
• Protein arrays: Antibody-based
• CSF proteomics: Biomarker discovery

Imaging Data

...

Introduction

This page provides an overview of datasets available for neurodegenerative disease research, including genomics, transcriptomics, proteomics, imaging, and clinical data. [@adni2024]

Major Data Resources

Genomics Databases

| Dataset | Disease | Samples | Access | [@ppmi2024]
|---------|---------|---------|--------| [@ampad2024]
| AMP-AD | AD | 2,000+ | NIAGADS |
| AMP-PD | PD | 10,000+ | AMP-PD |
| Target ALS | ALS | 1,000+ | Target ALS |
| ALSGene | ALS | 15,000+ | Project MinE |

Imaging Databases

| Dataset | Disease | Modalities | Access |
|---------|---------|------------|--------|
| ADNI | AD | MRI, PET | LONI |
| AIBL | AD | MRI, PET | Application |
| PPMI | PD | MRI, DAT | LONI |
| OASIS | AD | MRI | Public |
| DIAN | AD | MRI, PET | DIAN |
| GENIE | AD | MRI, PET, Genetics | LONI |

Clinical Databases

| Dataset | Disease | Patients | Access |
|---------|---------|----------|--------|
| NACC | AD, PD, FTD | 40,000+ | NACC |
| CLINICALtrials.gov | All | 50,000+ | Public |
| CurePSP | PSP, CBD | 5,000+ | Application |

Data Types

Genomic Data

• Whole genome sequencing: Rare variant discovery
• Exome sequencing: Protein-coding variants
• GWAS: Common variant associations
• RNA-seq: Gene expression

Proteomic Data

• Mass spectrometry: Protein quantification
• Protein arrays: Antibody-based
• CSF proteomics: Biomarker discovery

Imaging Data

• Structural MRI: Volume, cortical thickness
• Functional MRI: Connectivity, activity
• PET: Amyloid, [tau](/proteins/tau), glucose metabolism
• DTI: White matter integrity

Key Datasets by Disease

Alzheimer's Disease

| Resource | Type | Scale | Access |
|----------|------|-------|--------|
| AMP-AD | Multi-omics | Very large | Application |
| ADNI | Clinical, imaging | Large | Open |
| [ROS](/entities/reactive-oxygen-species)/MAP | Brain tissue | Large | Application |
| Mayo Clinic | Brain tissue | Large | Application |

Parkinson's Disease

| Resource | Type | Scale | Access |
|----------|------|-------|--------|
| AMP-PD | Multi-omics | Very large | Application |
| PPMI | Clinical, imaging | Large | Open |
| MJFF | Clinical | Large | Application |
| PD Genetics | GWAS | Very large | Open |

Amyotrophic Lateral Sclerosis

| Resource | Type | Scale | Access |
|----------|------|-------|--------|
| Target ALS | Tissue, data | Large | Application |
| Project MinE | Genomics | Very large | Application |
| PRO-ACT | Clinical | Very large | Open |
| NEALS | Clinical | Large | Application |

Data Access

Open Access Resources

ADNI: adni.loni.usc.edu

PPMI: www.ppmi-info.org

GWAS Catalog: www.ebi.ac.uk/gwas

AMP-AD: niaad.loni.usc.edu

Controlled Access

dbGaP: Application required

NIAGADS: Application required

AMP-PD: Application required

Synapse: Registration required

Data Standards

Common Formats

• BIDS: Brain imaging data
• VCF: Genetic variants
• MAF: Mutation annotation format
• COB: Clinical observations

Metadata Standards

• MIRAGE: Imaging metadata
• GEO: Gene expression
• ProteomeXchange: Proteomics

Related Pages

• [Datasets Index](/datasets)
• [Dataset Rankings](/datasets/rankings)
• [Research Projects](/projects)

See Also

• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/)
• [KEGG Pathways](https://www.genome.jp/kegg/pathway.html)

Topics

• [Datasets Overview](/datasets/overview) — This page
• [Datasets Rankings](/datasets/rankings) — Ranked list by research activity
• [Datasets Dashboard](/datasets/dashboard) — Data visualizations and metrics

Summary Statistics

• [Total Pages:** 19 Datasets pages in this section](/datasets)
• [Last Updated:** This section is actively maintained](/genes/th)

A-Z All Pages

• [Australian Imaging Biomarker Lifestyle (AIBL)](/datasets/aibl)
• [Allen Brain Atlas Datasets](/datasets/allen-brain-atlas)
• [Allen Brain Cell (ABC) Atlas](/datasets/allen-brain-cell-atlas)
• [Allen Cell Types Atlas](/datasets/cell-types-atlas)
• [Allen Human Brain Atlas](/datasets/allen-human-brain-atlas)
• [Allen Human Brain Atlas](/datasets/human-brain-atlas)
• [Allen Mouse Brain Atlas](/datasets/allen-mouse-brain-atlas)
• [Allen Mouse Brain Atlas](/datasets/mouse-brain-atlas)
• [Allen OpenScope Program](/datasets/allen-openscope)
• [BrainSpan Atlas](/datasets/brainspan-atlas)
• [Dataset Rankings](/datasets/rankings)
• [Datasets Dashboard](/datasets/dashboard)
• [Dominantly Inherited Alzheimer Network (DIAN)](/datasets/dian)
• [GENIE](/datasets/genie)
• [Human Connectome Project (referenced in NIH Blueprint Neuroimaging](/datasets/nih-blueprint-neuroimaging))
• [Open Access Series of Imaging Studies (OASIS)](/datasets/oasis)
• [Parkinson's Progression Markers Initiative (PPMI)](/datasets/ppmi)
• [UK Biobank](/datasets/uk-biobank)

[See all 14 datasets pages...](/datasets/rankings)

References

Unknown, ADNI. Data Access. 2024 (2024)

Unknown, PPMI. Data Portal. 2024 (2024)

Unknown, AMP-AD. Dataset Access. 2024 (2024)