Cacna1I Gene Calcium Voltage Gated Channel Subunit Alpha1 I is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
[@lipscombe2013] [@catterall2011]
Overview
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CACNA1I Gene - Calcium Voltage-Gated Channel Subunit Alpha1 I
Cacna1I Gene Calcium Voltage Gated Channel Subunit Alpha1 I is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
[@lipscombe2013] [@catterall2011]
Overview
Mermaid diagram (expand to render)
CACNA1I encodes the Cav3.3 calcium channel alpha1 subunit, a member of the T-type (low-voltage activated) calcium channel family. This gene is located on chromosome 22q12.3 and encodes a protein of 2,226 amino acids. Cav3.3 channels are characterized by their low-voltage activation, rapid inactivation, and important roles in neuronal pacemaking and thalamic signaling. [@zamponi2015]
Function
Cav3.3 (T-type) calcium channels are crucial for: [@evans2013]
Neuronal rhythmicity: Generate low-threshold calcium spikes in thalamic and cortical [neurons](/entities/neurons)
Thalamic oscillations: Critical for sleep spindles and absence seizures
Dendritic integration: Mediate back-propagation of calcium signals
The study of Cacna1I Gene Calcium Voltage Gated Channel Subunit Alpha1 I has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Brain Atlas Resources
Allen Human Brain Atlas: [Expression data for CACNA1I](https://human.brain-map.org/microarray/search/show?search_term=CACNA1I)
Allen Cell Type Atlas: [Cell type expression data](https://celltype.brain-map.org/)
The following diagram shows the key molecular relationships involving CACNA1I Gene - Calcium Voltage-Gated Channel Subunit Alpha1 I discovered through SciDEX knowledge graph analysis: