Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Therapy

**Molecular Mechanism and Rationale** The molecular foundation of this therapeutic approach centers on restoring the biosynthetic capacity for lipoxin A4 (LXA4), a specialized pro-resolving mediator (SPM), specifically within reactive astrocytes through targeted ALOX15 gene delivery. ALOX15 (15-lipoxygenase) serves as the rate-limiting enzyme in the biosynthetic pathway that converts arachidonic acid to 15-HETE, which is subsequently converted to LXA4 through a transcellular mechanism involving...