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CaMK1D Gene
Introduction
Camk1D Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@hook2001]
CAMK1D [@soderling2001]
Calcium/Calmodulin-Dependent Protein Kinase 1 Delta
| | | [@takemotokimura2020] |---|---| [@ghosh1995] | Symbol | CAMK1D | [@bito1997] | Full Name | Calcium/Calmodulin-Dependent Protein Kinase 1 Delta | [@wayman2008] | Chromosome | 10p13 | [@skelding2012] | NCBI Gene ID | [150094](https://www.ncbi.nlm.nih.gov/gene/150094) | | OMIM | [607981](https://www.omim.org/entry/607981) | | Ensembl ID | [ENSG00000139725](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139725) | | UniProt ID | [Q8JZR0](https://www.uniprot.org/uniprot/Q8JZR0) | | Encoded Protein | [CaMK1D Protein](/proteins/camk1d-protein) | | Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), [Inflammatory Diseases](/diseases/rheumatoid-arthritis) |
</div>
Overview
The CAMK1D gene encodes CaMK1D Protein, a Calcium/calmodulin-dependent protein kinase that plays critical roles in Serine/threonine protein kinase activated by calcium/calmodulin. This gene is implicated in the pathogenesis of several neurodegenerative diseases through its involvement in neuronal signaling, immune cell activation, cell proliferation.
Function
...
CaMK1D Gene
Introduction
Camk1D Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@hook2001]
CAMK1D [@soderling2001]
Calcium/Calmodulin-Dependent Protein Kinase 1 Delta
| | | [@takemotokimura2020] |---|---| [@ghosh1995] | Symbol | CAMK1D | [@bito1997] | Full Name | Calcium/Calmodulin-Dependent Protein Kinase 1 Delta | [@wayman2008] | Chromosome | 10p13 | [@skelding2012] | NCBI Gene ID | [150094](https://www.ncbi.nlm.nih.gov/gene/150094) | | OMIM | [607981](https://www.omim.org/entry/607981) | | Ensembl ID | [ENSG00000139725](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139725) | | UniProt ID | [Q8JZR0](https://www.uniprot.org/uniprot/Q8JZR0) | | Encoded Protein | [CaMK1D Protein](/proteins/camk1d-protein) | | Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), [Inflammatory Diseases](/diseases/rheumatoid-arthritis) |
</div>
Overview
The CAMK1D gene encodes CaMK1D Protein, a Calcium/calmodulin-dependent protein kinase that plays critical roles in Serine/threonine protein kinase activated by calcium/calmodulin. This gene is implicated in the pathogenesis of several neurodegenerative diseases through its involvement in neuronal signaling, immune cell activation, cell proliferation.
Function
CAMK1D encodes a member of the Ca2+/calmodulin-dependent protein kinase (CaMK) family with distinct tissue distribution. Unlike CaMK1A which is primarily neuronal, CaMK1D is expressed in various tissues including immune cells, hematopoietic cells, and [neurons](/entities/neurons). In immune cells, CaMK1D plays important roles in T cell activation, B cell function, and inflammatory responses. In neurons, CaMK1D is involved in synaptic plasticity and neuronal signaling. The kinase is activated by calcium influx and phosphorylates downstream targets involved in various cellular processes.
In Alzheimer's disease, CaMK1D expression and activity may be altered in affected brain regions. CaMK1D in [microglia](/cell-types/microglia-neuroinflammation) may modulate neuroinflammatory responses, which are key contributors to AD pathogenesis. In Parkinson's disease, CaMK1D signaling in immune cells may influence neuroinflammation and dopaminergic neuron survival. CaMK1D has also been implicated in various inflammatory and autoimmune diseases.
Expression
CAMK1D is expressed in various tissues including brain, spleen, thymus, and peripheral blood cells. In the brain, it is expressed in neurons and glial cells, with particular enrichment in immune-competent microglial cells.
The study of Camk1D Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
[Colbran RJ, Brown AM, Calcium/calmodulin-dependent protein kinases (2004)](https://pubmed.ncbi.nlm.nih.gov/15194107/)
[Hook SS, Means AR, Ca2+/CaM-dependent kinases: From activation by calcium to integrative regulation of cellular function (2001)](https://pubmed.ncbi.nlm.nih.gov/11264464/)
[Soderling TR, Stull JT, Structure and regulation of calcium/calmodulin-dependent protein kinases (2001)](https://pubmed.ncbi.nlm.nih.gov/11749377/)
[Takemoto-Kimura S, Suzuki K, Horigane S, et al, Roles of CaMK1 in neuronal development and function (2020)](https://pubmed.ncbi.nlm.nih.gov/32082191/)
[Ghosh A, Greenberg ME, Calcium signaling in neurons: Molecular mechanisms and cellular consequences (1995)](https://pubmed.ncbi.nlm.nih.gov/7716515/)
[Wayman GA, Lee YS, Tokumitsu H, et al, Calmodulin kinases: Modulators of neuronal development and plasticity (2008)](https://pubmed.ncbi.nlm.nih.gov/18817731/)
[Skelding KA, Rostas JA, Regulation of CaMKII in vivo: Mechanisms for spatial and temporal control (2012)](https://pubmed.ncbi.nlm.nih.gov/22292454/)