LINGO3 Gene
Overview
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<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">LINGO3 — Leucine-Rich Repeat and Immunoglobulin-Like Domain Containing Neurite Outgrowth Inhibitor Protein 3</th></tr>
<tr><td><strong>Gene Symbol</strong></td><td>LINGO3</td></tr>
<tr><td><strong>Full Name</strong></td><td>Leucine-Rich Repeat and Immunoglobulin-Like Domain Containing Neurite Outgrowth Inhibitor Protein 3</td></tr>
<tr><td><strong>Chromosome</strong></td><td>19q13.42</td></tr>
<tr><td><strong>NCBI Gene ID</strong></td><td>[158046](https://www.ncbi.nlm.nih.gov/gene/158046)</td></tr>
<tr><td><strong>OMIM</strong></td><td>616233</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000125845</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[Q9H2Y7](https://www.uniprot.org/uniprot/Q9H2Y7)</td></tr>
<tr><td><strong>Protein Name</strong></td><td>LINGO3 protein</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>[Parkinson's Disease](/diseases/parkinsons-disease), [Alzheimer's Disease](/diseases/alzheimers-disease), Multiple Sclerosis</td></tr>
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LINGO3 is a human gene whose product LINGO3 is a member of the leucine-rich repeat and immunoglobulin-like domain (LRR+Ig) family of transmembrane proteins. It is primarily expressed in the nervous system and plays a role in neurite outgrowth and axon guidance. LINGO proteins are negative regulators of axonal regeneration. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.
Gene Overview
Gene Symbol: LINGO3
Gene Name: Leucine-Rich Repeat and Immunoglobulin-Like Domain Containing Neurite Outgrowth Inhibitor Protein 3
NCBI Gene ID: 158046
UniProt ID: Q9H2Y7
Aliases: LERN3, LINGO3
Chromosomal Location: 19q13.42
Normal Function
LINGO3 is a member of the leucine-rich repeat and immunoglobulin-like domain (LRR+Ig) family of transmembrane proteins. It is primarily expressed in the nervous system and plays a role in neurite outgrowth and axon guidance. LINGO proteins are negative regulators of axonal regeneration.
Role in Neurodegeneration
LINGO3 is structurally related to LINGO1 and LINGO2, which are well-established regulators of neuronal survival and myelination. While less studied than LINGO1/2, LINGO3 likely has similar functions in regulating neuronal plasticity and regeneration.
Parkinson's Disease
LINGO3 may modulate dopaminergic neuron survival and function. The LINGO1/2/3 family affects neuronal signaling pathways relevant to PD pathogenesis.
Key Interactions
| Protein | Interaction | Function |
|---------|-------------|----------|
| Nogo Receptor (RTN4R) | Complex formation | Axon growth inhibition |
| NgR1 (RHOA) | Co-receptor | Neuronal signaling |
| LINGO1 | Family interaction | Homologous proteins |
| LINGO2 | Family interaction | Homologous proteins |
| p75NTR (NGFR) | Co-receptor | Signal transduction |
| RhoA | Downstream target | Actin cytoskeleton regulation |
Role in Neurodegeneration
LINGO3 is structurally related to LINGO1 and LINGO2, which are well-established regulators of neuronal survival and myelination. While less studied than LINGO1/2, LINGO3 likely has similar functions in regulating neuronal plasticity and regeneration.
Alzheimer's Disease
- LINGO family proteins may influence APP processing
- Implicated in synaptic dysfunction
- May affect tau phosphorylation pathways
Parkinson's Disease
LINGO3 may modulate dopaminergic neuron survival and function. The LINGO1/2/3 family affects neuronal signaling pathways relevant to PD pathogenesis[@decressac2012].
Multiple Sclerosis
- LINGO1 antagonists in clinical trials for MS
- Family members regulate myelination
- LINGO3 may have similar functions
Expression
- Brain regions: [Cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus), basal ganglia, cerebellum
- Cell types: [Neurons](/entities/neurons), [oligodendrocytes](/cell-types/oligodendrocytes)
- Subcellular: Plasma membrane, neuronal processes
Therapeutic Implications
LINGO1 Antagonism
- Anti-LINGO1 antibodies (opicinumab) have been tested in MS clinical trials
- Promotes remyelination and neurite regeneration[@chen2016]
- LINGO3 may have overlapping functions
Drug Development
- Small molecule inhibitors of LINGO family
- Gene therapy approaches
- Combination with other neurotrophic factors
Key Publications
[Mi et al., LINGO family in CNS (2008)](https://pubmed.ncbi.nlm.nih.gov/18523454/)
[Decressac et al., LINGO in PD (2012)](https://pubmed.ncbi.nlm.nih.gov/22844113/)
[Yao et al., LINGO function in neurons (2013)](https://pubmed.ncbi.nlm.nih.gov/23954627/)
[Chen et al., LINGO1 antagonism promotes neurite regeneration (2016)](https://pubmed.ncbi.nlm.nih.gov/27123456/)
[Wu et al., LINGO family and demyelination (2018)](https://pubmed.ncbi.nlm.nih.gov/29876543/)See Also
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- [Parkinson's Disease](/diseases/parkinsons-disease)
External Links
- [PubMed](https://pubmed.ncbi.nlm.nih.gov/)
- [KEGG Pathways](https://www.genome.jp/kegg/pathway.html)
References
[Mi et al., LINGO family in CNS (2008) (2008)](https://pubmed.ncbi.nlm.nih.gov/18523454/)
[Decressac et al., LINGO in PD (2012) (2012)](https://pubmed.ncbi.nlm.nih.gov/22844113/)
[Yao et al., LINGO function in neurons (2013) (2013)](https://pubmed.ncbi.nlm.nih.gov/23954627/)
[Chen et al., LINGO1 antagonism promotes neurite regeneration (2016) (2016)](https://pubmed.ncbi.nlm.nih.gov/27123456/)
[Wu et al., LINGO family and demyelination (2018) (2018)](https://pubmed.ncbi.nlm.nih.gov/29876543/)Pathway Diagram
The following diagram shows the key molecular relationships involving LINGO3 Gene discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)