NFE2L1 Gene

NFE2L1 — Nuclear Factor Erythroid 2 Like 1

Overview

Nfe2L1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Nfe2L1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@zhang2010]

NFE2L1 — Nuclear Factor Erythroid 2 Like 1

Overview

Nfe2L1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Nfe2L1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@zhang2010]

<div class="infobox infobox-gene"> [@lee2011]
<table> [@han2013]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">Nuclear Factor Erythroid 2 Like 1</th></tr> [@radhakrishnan2014]
<tr><td><strong>Gene Symbol</strong></td><td>NFE2L1</td></tr> [@kim2015]
<tr><td><strong>Full Name</strong></td><td>Nuclear Factor Erythroid 2 Like 1</td></tr> [@itoh2015]
<tr><td><strong>Chromosome</strong></td><td>7q11.23</td></tr> [@bentocormack2020]
<tr><td><strong>NCBI Gene ID</strong></td><td>[4779](https://www.ncbi.nlm.nih.gov/gene/4779)</td></tr>
<tr><td><strong>OMIM</strong></td><td>130120</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000118307</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[Q14145](https://www.uniprot.org/uniprot/Q14145)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, Cancer, Metabolic Disorders</td></tr>
</table>
</div>

Function

NFE2L1 encodes Nrf1 (Nuclear factor erythroid 2-related factor 1), a transcription factor that regulates antioxidant response and proteasome expression. Like Nrf2 (NFE2L2), Nrf1 binds to antioxidant response elements (ARE) to activate detoxifying enzymes and phase 2 metabolism genes. However, Nrf1 is primarily localized to the endoplasmic reticulum and requires proteolytic processing for activation. Nrf1 is essential for maintaining proteostasis under proteotoxic stress and is implicated in neurodegenerative diseases where proteasome function is impaired.

Expression

Widely expressed in brain ([neurons](/entities/neurons), [astrocytes](/entities/astrocytes), microglia), liver, and various tissues. High expression in regions vulnerable to neurodegeneration.

Disease Associations

| Disease | Mechanism |
|---------|-----------|
| Alzheimer's Disease | |
| Parkinson's Disease | |
| Huntington's Disease | |
| Cancer | |
| Metabolic Disorders | |

Interactions

| Partner | Interaction Type | Pathway |
|---------|-----------------|---------|

Research

Key Findings

• [Reference 1](https://pubmed.ncbi.nlm.nih.gov/) -
• [Reference 2](https://pubmed.ncbi.nlm.nih.gov/) -

Clinical Trials

No clinical trials directly targeting this gene are currently registered for neurodegenerative diseases.

Overview

Nfe2L1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Background

The study of Nfe2L1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

See Also

• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Amyloid Hypothesis](/mechanisms/amyloid-hypothesis)
• [Tau Pathology](/mechanisms/tau-pathology)
• [Parkinson's Disease](/diseases/parkinsons-disease)
• [Alpha-Synuclein](/mechanisms/alpha-synuclein)

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

External Resources

• [NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/)
• [UniProt](https://www.uniprot.org/uniprot/)
• [Ensembl](https://www.ensembl.org/)
• [GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=)

References

Pathway Diagram

The following diagram shows the key molecular relationships involving NFE2L1 Gene discovered through SciDEX knowledge graph analysis: