RAB11B - RAB11B
<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">RAB11B — RAB11B, Member RAS Oncogene Family</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>RAB11B</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>RAB11B, Member RAS Oncogene Family</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>19p13.2</td>
</tr>
<tr>
<td class="label">NCBI Gene</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/5876" target="_blank">5876</a></td>
</tr>
<tr>
<td class="label">Ensembl</td>
<td><a href="https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185236" target="_blank">ENSG00000185236</a></td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/Q9UQ90" target="_blank">Q9UQ90</a></td>
</tr>
<tr>
<td class="label">Diseases</td>
<td>[Parkinson's Disease](/diseases/parkinsons-disease), [Huntington's Disease](/diseases/huntingtons), Neurodevelopmental disorders</td>
</tr>
<tr>
<td class="label">Expression</td>
<td>Brain, [Neurons](/entities/neurons), Neurosecretory cells</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">29 edges</a></td>
</tr>
</table>
RAB11B — RAB11B, Member RAS Oncogene Family
...RAB11B - RAB11B
<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">RAB11B — RAB11B, Member RAS Oncogene Family</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>RAB11B</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>RAB11B, Member RAS Oncogene Family</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>19p13.2</td>
</tr>
<tr>
<td class="label">NCBI Gene</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/5876" target="_blank">5876</a></td>
</tr>
<tr>
<td class="label">Ensembl</td>
<td><a href="https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185236" target="_blank">ENSG00000185236</a></td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/Q9UQ90" target="_blank">Q9UQ90</a></td>
</tr>
<tr>
<td class="label">Diseases</td>
<td>[Parkinson's Disease](/diseases/parkinsons-disease), [Huntington's Disease](/diseases/huntingtons), Neurodevelopmental disorders</td>
</tr>
<tr>
<td class="label">Expression</td>
<td>Brain, [Neurons](/entities/neurons), Neurosecretory cells</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">29 edges</a></td>
</tr>
</table>
RAB11B — RAB11B, Member RAS Oncogene Family
Overview
Mermaid diagram (expand to render)
RAB11B (RAB11B, Member RAS Oncogene Family) is a member of the RAB GTPase family, which regulates vesicular trafficking in eukaryotic cells. Located on chromosome 19p13.2, RAB11B plays critical roles in neuronal function, particularly in synaptic vesicle recycling, neurotransmitter release, and axonal transport["@rabb"]. It is closely related to RAB11A, with which it shares functional overlap but exhibits distinct tissue expression patterns.
Function
RAB11B is a small GTPase that cycles between an active (GTP-bound) and inactive (GDP-bound) state. As a molecular switch, it regulates:
Synaptic Vesicle Recycling
RAB11B is involved in the recycling of synaptic vesicles after neurotransmitter release. It controls the reformation of synaptic vesicles from endosomes, a critical process for maintaining neurotransmission[@rabb].
Axonal Transport
RAB11B coordinates the movement of cargo vesicles along axons and dendrites, ensuring proper distribution of proteins and lipids to neuronal processes.
Neuropeptide Secretion
In neurosecretory cells, RAB11B regulates the trafficking of secretory granules, affecting neuropeptide release.
Autophagy
RAB11B participates in [autophagy](/entities/autophagy), specifically in the regulation of autophagosome formation and maturation. This is particularly relevant to neurodegenerative diseases where autophagy is often impaired.
Disease Associations
Parkinson's Disease (PD)
RAB11B has been implicated in Parkinson's disease pathogenesis through its role in:
- Lysosomal trafficking — PD is associated with lysosomal dysfunction; RAB11B regulates endocytic and lysosomal pathways
- [Alpha-synuclein](/proteins/alpha-synuclein) clearance — proper RAB11B function may facilitate autophagic clearance of alpha-synuclein aggregates
- Dopamine transport — RAB11B affects trafficking of dopamine receptors and transporters
Huntington's Disease (HD)
In HD, RAB11B dysfunction may contribute to:
- Impaired axonal transport of mutant [huntingtin protein](/proteins/huntingtin)
- Defects in synaptic vesicle recycling
- Altered autophagy leading to accumulation of protein aggregates
Neurodevelopmental Disorders
RAB11B variants have been associated with intellectual disability and autism spectrum disorders, reflecting its critical role in neuronal development and synaptic function.
Expression Pattern
RAB11B is enriched in:
- Cerebral [cortex](/brain-regions/cortex)
- [Hippocampus](/brain-regions/hippocampus) (CA1-CA3 regions)
- Cerebellum (Purkinje cells)
- Basal ganglia
- Spinal cord motor neurons
Interacting Proteins
RAB11B interacts with several key neuronal proteins:
- Rab11-FIP proteins — RAB11 effector proteins that mediate downstream functions
- Myosin V — motor protein for vesicle transport
- SNARE proteins — for membrane fusion
- Autophagy-related proteins — LC3, ATG proteins
Research Highlights
- RAB11B knockout mice show deficits in neurotransmitter release[@rab]
- RAB11B is downregulated in PD brain tissue
- Studies link RAB11B variants to autism and intellectual disability
See Also
- [Genes](/genes/)
- [RAB GTPases in neurons](/mechanisms/rab-gtpases-neuronal-trafficking/)
- [Parkinson's disease](/diseases/parkinsons-disease/)
- [Axonal transport](/mechanisms/axonal-transport)
External Links
- [NCBI Gene: RAB11B](https://www.ncbi.nlm.nih.gov/gene/5876)
- [Ensembl: RAB11B](https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185236)
- [UniProt: RAB11B](https://www.uniprot.org/uniprot/Q9UQ90)
References
[Unknown, RAB11B in synaptic vesicle recycling (n.d.)](https://pubmed.ncbi.nlm.nih.gov/14520455/)
[Unknown, RAB GTPases in neurodegeneration (n.d.)](https://pubmed.ncbi.nlm.nih.gov/32187528/)
[Unknown, RAB11 and Parkinson's disease (n.d.)](https://pubmed.ncbi.nlm.nih.gov/29227223/)Pathway Diagram
The following diagram shows the key molecular relationships involving RAB11B - RAB11B discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)