TRPM2 - Transient Receptor Potential Melastatin 2

TRPM2 Gene

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">TRPM2 - Transient Receptor Potential Melastatin 2</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>TRPM2</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Transient Receptor Potential Cation Channel Subfamily M Member 2</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>21q22.12</td>
</tr>
<tr>
<td class="label">HGNC ID</td>
<td>HGNC:12339</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000086848</td>
</tr>
<tr>
<td class="label">RefSeq</td>
<td>NM_003307</td>
</tr>
<tr>
<td class="label">Approach</td>
<td>Status</td>
</tr>
<tr>
<td class="label">TRPM2 Antagonists</td>
<td>Preclinical</td>
</tr>
<tr>
<td class="label">Calcium Channel Blockers</td>
<td>Approved</td>
</tr>
<tr>
<td class="label">Antioxidants</td>
<td>Approved</td>
</tr>
<tr>
<td class="label">Gene Therapy</td>
<td>Experimental</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/bipolar_disorder" style="color:#ef9a9a">BIPOLAR_DISORDER</a>, <a href="/wiki/bipolar" style="color:#ef9a9a">Bipolar</a>, <a href="/wiki/bipolar-disorder" style="color:#ef9a9a">Bipolar Disorder</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">82 edges</a></td>
</tr>
</table>

...

TRPM2 Gene

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">TRPM2 - Transient Receptor Potential Melastatin 2</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>TRPM2</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Transient Receptor Potential Cation Channel Subfamily M Member 2</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>21q22.12</td>
</tr>
<tr>
<td class="label">HGNC ID</td>
<td>HGNC:12339</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000086848</td>
</tr>
<tr>
<td class="label">RefSeq</td>
<td>NM_003307</td>
</tr>
<tr>
<td class="label">Approach</td>
<td>Status</td>
</tr>
<tr>
<td class="label">TRPM2 Antagonists</td>
<td>Preclinical</td>
</tr>
<tr>
<td class="label">Calcium Channel Blockers</td>
<td>Approved</td>
</tr>
<tr>
<td class="label">Antioxidants</td>
<td>Approved</td>
</tr>
<tr>
<td class="label">Gene Therapy</td>
<td>Experimental</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/bipolar_disorder" style="color:#ef9a9a">BIPOLAR_DISORDER</a>, <a href="/wiki/bipolar" style="color:#ef9a9a">Bipolar</a>, <a href="/wiki/bipolar-disorder" style="color:#ef9a9a">Bipolar Disorder</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">82 edges</a></td>
</tr>
</table>

Introduction

Trpm2 Transient Receptor Potential Melastatin 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2) encodes a calcium-permeable nonselective cation channel activated by oxidative stress and ADP-ribose. It is widely expressed in the brain and immune cells and plays important roles in oxidative stress response, insulin secretion, and cell death pathways. [@bai2019]

Gene Information

Molecular Function

TRPM2 is a unique channel with several distinctive features:

• Oxidative Stress Sensor: Activated by ADPR (adenosine diphosphate ribose) and oxidative stress
• Calcium Permeability: Allows Ca2+ influx upon activation
• NAD+ Metabolism: Linked to cellular NAD+ levels and energy status
• Cell Death Pathways: Involved in both apoptotic and necrotic cell death
• Thermo sensitivity: Modulated by temperature
• Channel Gating: Complex regulation by multiple stimuli

Disease Associations

Alzheimer's Disease

• Elevated TRPM2 expression in AD brain tissue
• [Amyloid-beta](/proteins/amyloid-beta) increases TRPM2 activity
• Contributes to calcium dysregulation and oxidative stress
• May accelerate neuronal death

Parkinson's Disease

• TRPM2 in dopaminergic neuron survival
• Oxidative stress activates TRPM2 in PD models
• Associated with neuroinflammation
• Therapeutic targeting potential

ALS

• TRPM2 activation in motor [neurons](/entities/neurons)
• Contributes to excitotoxicity
• Linked to oxidative stress pathways

Stroke/Ischemia

• Major mediator of ischemic neuronal death
• TRPM2 activation during stroke
• Potential therapeutic target

Diabetes

• TRPM2 in pancreatic beta cells
• Regulates insulin secretion
• Linked to metabolic disease

Bipolar Disorder

• TRPM2 variants associated with bipolar disorder
• Lithium may affect TRPM2 function
• Calcium signaling dysregulation

Structure

The TRPM2 protein contains:

• Six Transmembrane Domains: Standard TRP channel architecture
• N-terminal ADPR Binding Domain: Unique feature for ADP-ribose activation
• C-terminal Domain: Contains regulatory elements
• Tetrameric Assembly: Forms functional homomers

Therapeutic Targeting

Animal Models

• TRPM2 Knockout Mice: Protected from ischemic injury
• Transgenic Overexpression: Enhanced oxidative stress damage
• Behavioral Studies: Learning, motor function

Background

The study of Trpm2 Transient Receptor Potential Melastatin 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

See Also

• TRP Channels
• [Ion Channels](/mechanisms/ion-channel-dysfunction)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)
• Bipolar Disorder
• [Oxidative Stress](/mechanisms/oxidative-stress)
• [Neuroinflammation](/mechanisms/neuroinflammation-pathway)

External Links

• [NCBI Gene: TRPM2](https://www.ncbi.nlm.nih.gov/gene/7226)
• [UniProt: TRPM2](https://www.uniprot.org/uniprot/Q9NP86)
• [GeneCards: TRPM2](https://www.genecards.org/cgi-bin/carddisp.pl?gene=TRPM2)
• [OMIM: TRPM2](https://www.omim.org/entry/604749)

References

Nazıroğlu M, et al, (2012) (2012)

Bai AX, et al, (2019) (2019)

Huang Y, et al, (2018) (2018)

Kheradpezhouh E, et al, (2017) (2017)

Pathway Diagram

The following diagram shows the key molecular relationships involving TRPM2 - Transient Receptor Potential Melastatin 2 discovered through SciDEX knowledge graph analysis: