Circadian Rhythm Entrainment of Reactive Astrocytes

**Molecular Mechanism and Rationale** The circadian rhythm entrainment of reactive astrocytes represents a novel therapeutic paradigm leveraging the intrinsic temporal regulation of glial cell phenotypes through the master circadian transcription factor BMAL1 (Brain and Muscle ARNT-Like 1). BMAL1, forming a heterodimer with CLOCK (Circadian Locomotor Output Cycles Kaput), serves as the positive arm of the molecular circadian clock machinery, driving rhythmic gene expression through E-box-mediat...