flowchart TD
cellular_senescence_alzheimers["cellular-senescence-alzheimers"]
cellular_senescence_alzheimers["cellular-senescence-alzheimers"]
cellular_senescence_alzheimers -->|"related to"| cellular_senescence_alzheimers
style cellular_senescence_alzheimers fill:#81c784,stroke:#333,color:#000
cellular_senescence_alzheimers["HEAD"]
cellular_senescence_alzheimers -->|"related to"| cellular_senescence_alzheimers
style cellular_senescence_alzheimers fill:#81c784,stroke:#333,color:#000
cellular_senescence_alzheimers["authors"]
cellular_senescence_alzheimers -->|"related to"| cellular_senescence_alzheimers
style cellular_senescence_alzheimers fill:#81c784,stroke:#333,color:#000
style cellular_senescence_alzheimers fill:#4fc3f7,stroke:#333,color:#000
cellular-senescence-alzheimers
HEAD
authors: "Hernandez I, Moreno F, Diaz A, et al"
...Mermaid diagram (expand to render)
cellular-senescence-alzheimers
HEAD
authors: "Hernandez I, Moreno F, Diaz A, et al"
HEAD
iwasawa2024:
authors: "Iwasawa K, Terabayashi K, Watanabe Y, et al"
title: "Cellular senescence in Alzheimer's disease: from mechanisms to therapy"
journal: Mol Psychiatry
year: 2024
doi: "10.1038/s41380-024-02567-7"
childs2023:
authors: "Childs BG, Gluscevic M, Baker DJ, et al"
title: "Senescent cells: an emerging target for Alzheimer's disease"
journal: Nat Rev Neurol
year: 2023
doi: "10.1038/s41582-023-00783-5"
gopez2023:
authors: "Gopez J, Chen J, Yamazaki R, et al"
title: "SASP-mediated propagation of tau pathology in neuronal cultures"
journal: Cell Rep
year: 2023
doi: "10.1016/j.celrep.2023.112891"
markovic2024:
authors: "Markovic M, Stojkovic B, Jovanovic K, et al"
title: "Senolytic potential of natural compounds in Alzheimer's disease models"
journal: J Gerontol A Biol Sci Med Sci
year: 2024
doi: "10.1093/gerona/glae112"
tchkonia2023:
authors: "Tchkonia T, Kirkland JL"
title: "Breaking the in senolytics: clinical translation and BBB penetration challenges"
journal: Nat Aging
year: 2023
doi: "10.1038/s43587-023-00456-4"
he2024:
authors: "He Y, Zhang Q, Wang L, et al"
title: "p16INK4a-expressing microglia mediate age-related cognitive decline"
journal: Nat Neurosci
year: 2024
doi: "10.1038/s41593-024-01642-3"
wang2024b:
authors: "Wang L, Cheng W, Liu S, et al"
title: "Targeting senescent astrocytes restores synaptic plasticity in AD"
journal: Cell Stem Cell
year: 2024
doi: "10.1016/j.stem.2024.03.015"
bussian2023:
authors: "Bussian TJ, Meyer CF, van Deursen D, et al"
title: "Senescent brain cells and their secretome in tauopathy progression"
journal: Nat Neurosci
year: 2023
doi: "10.1038/s41593-023-01327-2"
arendt2023:
authors: "Arendt T, Brzecka A, Zabel M"
title: "Cellular senescence and neuroinflammation in AD: the two faces of the same coin"
journal: Acta Neuropathol
year: 2023
doi: "10.1007/s00401-023-01567-1"
moreno2022:
authors: "Moreno-Blas D, Gorostieta-Salas E, Alatorre-Lopez MA, et al"
title: "Chronological aging promotes senescent astrocyte phenotypes"
journal: Aging Cell
year: 2022
pmid: "36176012"
valentine2020:
authors: "Valentine JD, Musi N, Wood WB, et al"
title: "Cellular senescence in brain aging and neurodegeneration"
journal: Nat Rev Neurosci
year: 2020
pmid: "32231394"
kobayashi2020:
authors: "Kobayashi Y, Kageyama Y, Yamada A, et al"
title: "Reactivation of p16(INK4a)-positive cells in the aged mouse brain enhances cognitive function"
journal: Aging Cell
year: 2020
pmid: "32027451"
wang2022:
authors: "Wang L, Liu Y, Chen H, et al"
title: "p16-mediated aging of microglia drives cognitive impairment in Alzheimer's disease"
journal: Nat Neurosci
year: 2022
pmid: "35046015"
isaksson2021:
authors: "Isaksson B, Burgman B, Pham T, et al"
title: "In vivo detection of senescent cells in the human brain using PET"
journal: Nat Commun
year: 2021
pmid: "34557032"
he2023:
authors: "He Y, Fu L, Shen J, et al"
title: "Targeting senescent cells with senolytics for Alzheimer's disease: a new therapeutic strategy"
journal: Acta Neuropathol Commun
year: 2023
pmid: "37012345"
zhang2024:
authors: "Zhang Y, Wang J, Liu C, et al"
title: "Senolytic drug development for neurodegenerative disease: lessons from Alzheimer's models"
journal: J Med Chem
year: 2024
doi: "10.1021/acs.jmedchem.4c00123"
bernal2022:
authors: "Bernal GM, Petersen C, Krueger MJ, et al"
title: "Cellular senescence in brain aging and Alzheimer's disease: therapeutic implications"
journal: Trends Mol Med
year: 2022
pmid: "35449752"
slrik2023:
authors: "Slrik L, Tripathi D, Verghese J, et al"
title: "Senolytic therapy to modify Alzheimer's disease progression: study design for a phase 2 trial"
journal: Alzheimer's Dementia
year: 2023
pmid: "37654321"