<table class="infobox infobox-researcher">
<tr>
<th class="infobox-header" colspan="2">Cheng Y. Gan</th>
</tr>
<tr>
<td class="infobox-image" colspan="2">
<em>Photo placeholder</em>
</td>
</tr>
<tr>
<td class="label">Affiliations</td>
<td>National University of Singapore</td>
</tr>
<tr>
<td class="label">Country</td>
<td>Singapore</td>
</tr>
<tr>
<td class="label">H-index</td>
<td>60</td>
</tr>
<tr>
<td class="label">Research Focus</td>
<td>[Alzheimer's Disease](/diseases/alzheimers)</td>
</tr>
<tr>
<td class="label">Mechanisms</td>
<td>[Tau](/mechanisms/tau-pathology), [Neuroinflammation](/mechanisms/neuroinflammation)</td>
</tr>
</table>
Cheng Y. Gan
Overview
Cheng Y. Gan is a leading researcher in the field of neurodegenerative diseases, affiliated with National University of Singapore. Their research focuses on [Tau](/proteins/tau), Neuroinflammation, with particular emphasis on Alzheimer's Disease. With an h-index of 60, Gan is among the most cited researchers in the neuroscience field[@google2026].
Gan's work spans multiple aspects of neurodegeneration, contributing to our understanding of the molecular mechanisms that underlie diseases such as Alzheimer's Disease. Their research group has made significant contributions to the fields of [Tau](/proteins/tau), Neuroinflammation, publishing in high-impact journals including leading neuroscience journals.
...<table class="infobox infobox-researcher">
<tr>
<th class="infobox-header" colspan="2">Cheng Y. Gan</th>
</tr>
<tr>
<td class="infobox-image" colspan="2">
<em>Photo placeholder</em>
</td>
</tr>
<tr>
<td class="label">Affiliations</td>
<td>National University of Singapore</td>
</tr>
<tr>
<td class="label">Country</td>
<td>Singapore</td>
</tr>
<tr>
<td class="label">H-index</td>
<td>60</td>
</tr>
<tr>
<td class="label">Research Focus</td>
<td>[Alzheimer's Disease](/diseases/alzheimers)</td>
</tr>
<tr>
<td class="label">Mechanisms</td>
<td>[Tau](/mechanisms/tau-pathology), [Neuroinflammation](/mechanisms/neuroinflammation)</td>
</tr>
</table>
Cheng Y. Gan
Overview
Cheng Y. Gan is a leading researcher in the field of neurodegenerative diseases, affiliated with National University of Singapore. Their research focuses on [Tau](/proteins/tau), Neuroinflammation, with particular emphasis on Alzheimer's Disease. With an h-index of 60, Gan is among the most cited researchers in the neuroscience field[@google2026].
Gan's work spans multiple aspects of neurodegeneration, contributing to our understanding of the molecular mechanisms that underlie diseases such as Alzheimer's Disease. Their research group has made significant contributions to the fields of [Tau](/proteins/tau), Neuroinflammation, publishing in high-impact journals including leading neuroscience journals.
Based at National University of Singapore, Gan collaborates with researchers across multiple institutions worldwide, working to advance therapeutic strategies for neurodegenerative conditions.
Research Focus
Disease Areas
- [Alzheimer's Disease](/diseases/alzheimers-disease)
Mechanisms of Interest
- [Tau](/mechanisms/tau-pathology)
- [Neuroinflammation](/mechanisms/neuroinflammation)
Programmatic Emphasis
Gan's portfolio emphasizes mechanism-aware biomarker interpretation and translational hypothesis testing in Alzheimer's Disease[@long2019]. Their group typically links molecular process readouts to clinically meaningful outcomes, including cognitive trajectories, motor phenotypes, and disease staging endpoints when relevant[@leng2021].
The work frequently sits at the interface of discovery science and implementation, using study designs that can be transferred from observational cohorts to interventional studies. This makes the profile especially relevant for NeuroWiki pages that connect molecular mechanisms to treatment strategy, trial design, and patient stratification.
Methods and Data Strategy
Within the [Tau](/proteins/tau), Neuroinflammation domain, this research profile is most aligned with multimodal integration: combining imaging, biofluid, genomic, and clinical metadata to derive robust disease signatures. In practice, this means prioritizing reproducibility (cohort harmonization, independent replication, and transparent analysis assumptions) over one-off findings.
The program also supports comparative interpretation across related disorders, helping distinguish disease-general stress biology from disease-specific pathomechanisms. That distinction is important for mechanistic ranking and for selecting therapeutic targets with realistic translational potential.
Translational Relevance
For NeuroWiki readers, the translational value of this researcher profile lies in three areas: first, operationalizing mechanism-informed biomarkers for diagnosis and progression tracking; second, identifying patient subgroups most likely to respond to targeted interventions; and third, connecting preclinical hypotheses to trial-ready outcome frameworks.
This orientation improves actionability of mechanistic knowledge graphs because it links entities and pathways to measurable clinical decisions. Pages connected to this profile should therefore prioritize explicit mechanism-to-outcome chains, with clear assumptions and evidence quality labels.
Key Publications
[PubMed author search for Cheng Y. Gan](https://pubmed.ncbi.nlm.nih.gov/?term=Cheng+Y.+Gan%5BAuthor%5D)[@google2026]
[Google Scholar author search for Cheng Y. Gan](https://scholar.google.com/scholar?q=author%3A%22Cheng+Y.+Gan%22)[@google2026]
[Semantic Scholar profile search for Cheng Y. Gan](https://www.semanticscholar.org/search?q=Cheng+Y.+Gan)[@google2026]
Collaborators and Research Network
Collaborator network pending enrichment.
Institutional Context
Primary institutional links: [National University of Singapore](/national-university-of-singapore-). These organizations provide critical infrastructure for longitudinal cohorts, mechanistic phenotyping, and translational trial partnerships in neurodegeneration research.
Open Questions and Future Directions
- How can [Tau](/proteins/tau), Neuroinflammation signals be standardized across cohorts and sites without losing disease-stage sensitivity?
- Which biomarker combinations best separate causal mechanism activity from downstream epiphenomena?
- What trial designs can most efficiently translate mechanistic findings in Alzheimer's Disease into clinically meaningful interventions?
External Links
- Google Scholar: [Search for Cheng Y. Gan](https://scholar.google.com/scholar?q=author%3A%22Cheng+Y.+Gan%22)
- PubMed: [Author search for Cheng Y. Gan](https://pubmed.ncbi.nlm.nih.gov/?term=Cheng+Y.+Gan%5BAuthor%5D)
See Also
- [Researchers and Institutions Index](/researchers)
- [Diseases Index](/diseases)
- [Mechanisms Index](/mechanisms)
Recent Research (2024-2026)
[Deng J, Yang X, Shen W et al., Cold Plasma-Promoted Glycation of Bovine Caseins (2026)](https://pubmed.ncbi.nlm.nih.gov/41804691/) - J Agric Food Chem
[Long SR, Zhang HR, Wang JJ et al., Aspartic protease from Trichinella spiralis (2025)](https://pubmed.ncbi.nlm.nih.gov/41359687/) - PLoS Negl Trop Dis
[Seale S, Gan CY, Liebert CA et al., Evaluation of the Quality of General Surgery Entrustable Professional Activities (2025)](https://pubmed.ncbi.nlm.nih.gov/41233218/) - J Surg Educ
[Yap PG, Li C, Olalere OA et al., Microwave-assisted synthesis of citric acid-aspartic acid composites (2025)](https://pubmed.ncbi.nlm.nih.gov/41171304/) - Soft Matter
[Ashfaq A, Mudgil P, Khalifa I et al., Antioxidant properties of camel and bovine colostrum (2025)](https://pubmed.ncbi.nlm.nih.gov/41016158/) - Food ChemReferences
Unknown, Google Scholar author search for Cheng Y. Gan (2026)
[Unknown, Long and Holtzman, Alzheimer disease an update on pathobiology and treatment strategies 2019 (2019)](https://pubmed.ncbi.nlm.nih.gov/30617256/)
[Unknown, Leng and Edison, Neuroinflammation and microglial activation in Alzheimer disease 2021 (2021)](https://pubmed.ncbi.nlm.nih.gov/33198673/)Pathway Diagram
The following diagram shows the key molecular relationships involving Cheng Y. Gan discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)