🧫
Bioinformatics analysis and hub gene identification
active
experiment
Created: 2026-04-10T22:35:16
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-1511b30e-82a8-4dbd-a5f6-3a12348e2b3f
🧫 Experiment Protocol
ExploratoryAlzheimer's disease11 hub genes involved in vascular contraction and circadian regulationcomputational analysis of transcriptomic dataproposed
Integrative bioinformatics analysis was conducted including functional and pathway enrichment analysis, protein-protein interaction (PPI) network construction, ClueGo module analysis, and CFG prioritization to identify core genes regulating cerebral microvascular function. This computational approach aimed to prioritize key regulatory genes from the large set of differentially expressed transcripts and understand their functional relationships.
PRIMARY OUTCOME
identification of 11 hub genes
EXPECTED OUTCOMES
Identification of key regulatory genes for microvascular function
SUCCESS CRITERIA
Convergent evidence from multiple bioinformatics approaches
PROTOCOL
Functional enrichment analysis, PPI network construction, ClueGo module analysis, CFG prioritization
LINKED HYPOTHESES
h-73e29e3a· Synaptic Vesicle Tau Capture Inhibitionh-var-97b18b880d· ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Peroxidationh-fdaae8d9· Trans-Synaptic Adhesion Molecule Modulationh-4dd0d19b· LRP1-Dependent Tau Uptake Disruptionh-b234254c· TREM2-mediated microglial tau clearance enhancement
Source: PMID 41940832 ↗
🧫 Experiment Extras
PATHWAY
vascular contraction and circadian rhythm regulation
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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