🧫
Single nucleus RNA-seq and ATAC-seq of postmortem PD brain tissue (n=19) and controls (n=14) identified 13 microglial subpopulations; CD83+ HIF1A- microglia were specifically depleted in substantia nigra in PD with unique chromatin signature, and this population normally shows brainstem regional spe
active
experiment
Created: 2026-04-27T23:19:02
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-2cdb9960aaa3
🧫 Experiment Protocol
Gene ExpressionParkinson's diseaseCD83postmortem_human_tissueextracted
10x Genomics Chromium platform for single nucleus multiome RNA-seq and ATAC-seq; four brain regions analyzed to compare neurodegeneration severity
PRIMARY OUTCOME
Single nucleus RNA-seq and ATAC-seq of postmortem PD brain tissue (n=19) and controls (n=14) identified 13 microglial subpopulations; CD83+ HIF1A- microglia were specifically depleted in substantia nigra in PD with unique chromatin signature, and this population normally shows brainstem regional specificity.
LINKED HYPOTHESES
Source: pmid_37292857
🧫 Experiment Extras
PATHWAY
microglial activation and neuroinflammation
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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