🧫
Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in cancer driver genes in AD brain, with recurrent mutations in clonal hematopoiesis genes and up to 40% of microglia carrying pathogenic sSNVs.
active
experiment
Created: 2026-04-27T23:18:28
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-6ca747a7175f
🧫 Experiment Protocol
Genetic AssociationAlzheimer's diseasecancer driver genes; CSF1R; clonal hematopoiesis genesin_vivoextracted
Molecular-barcoded deep sequencing (>1000X coverage); analysis of sSNVs and sIndels in cancer driver genes
PRIMARY OUTCOME
Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in cancer driver genes in AD brain, with recurrent mutations in clonal hematopoiesis genes and up to 40% of microglia carrying pathogenic sSNVs.
LINKED HYPOTHESES
Source: pmid_38260600
🧫 Experiment Extras
PATHWAY
clonal hematopoiesis; microglial clonal expansion (MiCE)
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.