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Longitudinal plasma biomarker study measuring Aβ42:Aβ40 ratio, p-tau181, NfL, and GFAP at midlife and late life in 1525 ARIC participants found that decreasing Aβ42:Aβ40 and increasing p-tau181, NfL, and GFAP over time were associated with incident all-cause dementia, with the strongest late-life as
active
experiment
Created: 2026-04-27T23:24:34
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-6fc9683e936c
🧫 Experiment Protocol
ClinicalAlzheimer's diseaseAPOEhumanextracted
Plasma biomarkers measured using Quanterix Simoa platform; incident dementia ascertained from neuropsychological assessments, participant contact, and medical record surveillance from 2012-2019.
PRIMARY OUTCOME
Longitudinal plasma biomarker study measuring Aβ42:Aβ40 ratio, p-tau181, NfL, and GFAP at midlife and late life in 1525 ARIC participants found that decreasing Aβ42:Aβ40 and increasing p-tau181, NfL, and GFAP over time were associated with incident all-cause dementia, with the strongest late-life association for NfL (HR 1.92).
Source: pmid_39068543
🧫 Experiment Extras
PATHWAY
lipid metabolism/apolipoprotein function
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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