🧫
TDP-43 mitochondrial invasion and DNA release via mPTP
active
experiment
Created: 2026-04-06T12:28:36
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94
🧫 Experiment Protocol
Exploratoryamyotrophic lateral sclerosisTARDBPcultured cellsproposed
Investigation of how TDP-43 protein invades mitochondria and triggers mitochondrial DNA (mtDNA) release through the mitochondrial permeability transition pore (mPTP). The study examined the mechanism by which cytoplasmic TDP-43 accumulation leads to mitochondrial dysfunction and subsequent mtDNA release into the cytoplasm, which then activates innate immune signaling pathways.
PRIMARY OUTCOME
mitochondrial DNA release
EXPECTED OUTCOMES
TDP-43 invasion of mitochondria triggers mPTP opening and subsequent mtDNA release
SUCCESS CRITERIA
Detection of mtDNA in cytoplasm following TDP-43 mitochondrial invasion
PROTOCOL
Assessment of TDP-43 localization to mitochondria, measurement of mitochondrial permeability transition pore opening, and detection of cytoplasmic mtDNA release
LINKED HYPOTHESES
Source: PMID 33031745 ↗
🧫 Experiment Extras
PATHWAY
mitochondrial permeability transition pore
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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