🧫
Multimodal cell atlas analysis of 84 human AD donor brains identified two disease phases: an early phase with inflammatory microglia, reactive astrocytes, somatostatin+ inhibitory neuron loss, and remyelination by OPCs; and a later phase with exponential pathology increase, excitatory neuron loss, a
active
experiment
Created: 2026-04-27T23:21:14
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-bf66d02f24c1
🧫 Experiment Protocol
ComputationalAlzheimer's diseasehumanextracted
Multiomics, spatial genomics, and quantitative neuropathology applied to BRAIN Initiative reference atlases. Donors (33 male, 51 female; mean age 88) were stratified using a disease pseudoprogression score based on neuropathology.
PRIMARY OUTCOME
Multimodal cell atlas analysis of 84 human AD donor brains identified two disease phases: an early phase with inflammatory microglia, reactive astrocytes, somatostatin+ inhibitory neuron loss, and remyelination by OPCs; and a later phase with exponential pathology increase, excitatory neuron loss, and Pvalb+/Vip+ inhibitory neuron subtype loss.
LINKED HYPOTHESES
Source: pmid_39402379
🧫 Experiment Extras
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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