🧫
Integrated multiomics and spatial genomics analysis of 84 human donors revealed two distinct disease phases: an early phase with inflammatory microglia, reactive astrocytes, loss of somatostatin+ inhibitory neurons, and oligodendrocyte precursor cell remyelination; and a later phase with exponential
active
experiment
Created: 2026-04-27T23:23:27
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-e980ab26a4ed
🧫 Experiment Protocol
NeuropathologyAlzheimer's diseasehumanextracted
Quantitative neuropathology used to assign donors along disease pseudoprogression score; findings replicated in other major AD studies; BRAIN Initiative reference atlases integrated
PRIMARY OUTCOME
Integrated multiomics and spatial genomics analysis of 84 human donors revealed two distinct disease phases: an early phase with inflammatory microglia, reactive astrocytes, loss of somatostatin+ inhibitory neurons, and oligodendrocyte precursor cell remyelination; and a later phase with exponential pathology increase and loss of excitatory and Pvalb+/Vip+ inhibitory neurons.
LINKED HYPOTHESES
Source: pmid_39402379
🧫 Experiment Extras
PATHWAY
neuroinflammation
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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