🧫
TDP-43 pathology prevalence and distribution in AD cases
active
experiment
Created: 2026-04-06T12:29:12
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-f3173807-127f-4beb-abfc-64d934416c78
🧫 Experiment Protocol
ExploratoryAlzheimer's diseaseTARDBPhuman postmortem brain tissueproposed
Neuropathological examination of Alzheimer's disease cases to determine the prevalence and distribution pattern of TDP-43 inclusions. The study found that TDP-43 inclusions occur in up to 57% of AD cases, most commonly in a limbic distribution pattern, with or without associated hippocampal sclerosis. The inclusions consist of phosphorylated and truncated forms of TDP-43 protein forming cytoplasmic inclusion bodies. In some cases, TDP-43 deposits were observed co-localizing with neurofibrillary tangles in neurons, suggesting potential interaction between tau and TDP-43 pathologies.
PRIMARY OUTCOME
prevalence and distribution of TDP-43 pathology
EXPECTED OUTCOMES
characterization of TDP-43 pathology frequency and anatomical distribution in AD
SUCCESS CRITERIA
detection and quantification of TDP-43 inclusions in brain regions
PROTOCOL
neuropathological examination of AD brain tissue using immunohistochemistry for phosphorylated TDP-43
LINKED HYPOTHESES
Source: PMID 34930382 ↗
🧫 Experiment Extras
PATHWAY
RNA processing and gene expression regulation
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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