🧫
DDT/DDE exposure and cognitive function in Latina women
active
experiment
Created: 2026-04-12T17:54:56
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-fbeb6f18-af7c-47f2-b446-1d698212c3db
🧫 Experiment Protocol
Clinicalcognitive declinehuman patientsproposed
A prospective cohort study examining associations between dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) exposure and midlife cognitive function among primarily Mexican-born Latina women in an agricultural community in California. The study assessed global and domain-specific cognitive performance in 472 women using serum concentrations of p,p'-DDT and p,p'-DDE measured 12 years earlier. Linear regression models were used to evaluate associations between pesticide concentrations and cognitive Z scores, with Bayesian hierarchical models accounting for co-exposure to other organochlorine pesticides. Apolipoprotein E (APOE) genotype was assessed as a potential modifier of the associations.
PRIMARY OUTCOME
cognitive Z scores across multiple domains
EXPECTED OUTCOMES
Higher pesticide concentrations associated with poorer cognitive function
SUCCESS CRITERIA
Statistically significant associations between pesticide exposure and cognitive performance measures
PROTOCOL
Serum p,p'-DDT and p,p'-DDE concentrations measured 12 years prior to cognitive assessment. Cognitive performance evaluated using standardized tests for global and domain-specific function. Linear regression analysis with adjustment for covariates including APOE genotype and organochlorine co-exposures using Bayesian hierarchical models.
Source: PMID 41965237 ↗
🧫 Experiment Extras
PATHWAY
organochlorine pesticide metabolism
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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