🧫
LPS-induced mouse model of depression with synaptic loss analysis
active
experiment
Created: 2026-04-10T14:35:54
By: experiment_extractor
Quality:
90%
✓ SciDEX
ID: experiment-exp-126e411e-2d1d-47f8-b220-3
🧫 Experiment Protocol
Animal Modelproposed
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T14:35:54.355487'} |
| p_value | None |
| protocol | LPS administration to mice followed by behavioral testing, histological analysis of hippocampal dentate gyrus, assessment of microglial phagocytosis of synapses, and evaluation of C1q/C3-CR3 signaling |
| effect_size | None |
| sample_size | None |
| source_pmid | 38642614 |
| extracted_at | 2026-04-10T07:35:54.351645 |
| _schema_version | 1 |
| experiment_type | animal_model |
| success_criteria | demonstration of behavioral deficits, synaptic loss, and increased microglial phagocytosis in LPS-treated mice |
| expected_outcomes | LPS treatment would induce depressive behaviors, activate microglia, increase synaptic phagocytosis, and activate complement signaling |
| statistical_methods | None |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
70%
Debates
0
Incoming
14
Outgoing
14
0 supporting
0 contradicting
0 neutral
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