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Single nuclei multiomic profiling (transcriptomes, epigenomes, spatial coordinates) of 84 human donors spanning AD pathology spectrum mapped to a common cell type reference. Analysis revealed early reduction of Somatostatin-expressing neuronal subtypes and late decreases in supragranular intratelenc
active
experiment
Created:
By: experiment_extractor
Quality:
50%
✓ SciDEX
ID: experiment-exp-5b95208cae8c
🧫 Experiment Protocol
Cell Biologyproposed
SUMMARY
Single nuclei multiomic profiling (transcriptomes, epigenomes, spatial coordinates) of 84 human donors spanning AD pathology spectrum mapped to a common cell type reference. Analysis revealed early reduction of Somatostatin-expressing neuronal subtypes and late decreases in supragranular intratelencephalic-projecting excitatory and Parvalbumin-expressing neurons, with increases in disease-associated microglial and astrocytic states.
METHODOLOGY NOTES
Image-based quantitative neuropathology used to create continuous disease pseudoprogression score; single nuclei multiomic profiling with transcriptome and epigenome measurement; spatial transcriptomics; BRAIN Initiative Cell Census Network methodology; publicly available resource at SEA-AD.org
N = {'case': None, 'total': 84, 'units': 'subjects', 'control': None}tissue: middle temporal gyrusspecies: homo_sapiens
▸Metadatasource: {'pmid': '37292694', 'type': 'paper', 'e
| source | {'pmid': '37292694', 'type': 'paper', 'extracted_by': 'llm_extraction_v1'} |
| tissue | middle temporal gyrus |
| species | homo_sapiens |
| summary | Single nuclei multiomic profiling (transcriptomes, epigenomes, spatial coordinates) of 84 human donors spanning AD pathology spectrum mapped to a common cell type reference. Analysis revealed early re |
| sample_size | {'case': None, 'total': 84, 'units': 'subjects', 'control': None} |
| model_system | human |
| _schema_version | 1 |
| experiment_type | cell_biology |
| methodology_notes | Image-based quantitative neuropathology used to create continuous disease pseudoprogression score; single nuclei multiomic profiling with transcriptome and epigenome measurement; spatial transcriptomi |
| replication_status | novel |
| extraction_metadata | {'needs_review': False, 'extraction_date': '2026-04-28T06:15:18.507379+00:00', 'extraction_notes': '', 'extraction_confidence': 0.5} |
| statistical_evidence | None |
📊 Evidence Profile
Evidence Balance
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Certainty
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Debates
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0 supporting
0 contradicting
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