High fiber diet effects on gut microbiome and neuroinflammation in aging

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active

experiment Created: 2026-04-10T23:12:36 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-981d6333-ef1b-486a-b6dd-1

🧫 Experiment Protocol Animal Modelproposed

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T23:12:36.947913'}
p_value	None
protocol	4-week dietary intervention with either 1% cellulose (low fiber) or 5% inulin (high fiber) diet, followed by gut microbiome analysis, SCFA measurement, histological assessment of colon inflammation, a
effect_size	None
sample_size	None
source_pmid	30154787
extracted_at	2026-04-10T16:12:36.897393
_schema_version	1
experiment_type	animal_model
success_criteria	Significant changes in gut microbiome composition, increased SCFA levels, reduced colonic inflammation scores, and altered microglial gene expression toward anti-inflammatory profile
expected_outcomes	High fiber diet would increase beneficial gut bacteria, increase SCFA production, reduce intestinal inflammation, and promote anti-inflammatory microglial phenotype
statistical_methods	None

📊 Evidence Profile

Evidence Balance

+0%

Certainty

30%

Debates

0

Incoming

6

Outgoing

5

0 supporting 0 contradicting 0 neutral

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💬 Discussion