Mouse Cdk5, p35, and p39 mutations in neuronal migration

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Mouse Cdk5, p35, and p39 mutations in neuronal migration

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experiment Created: 2026-04-06T12:34:08 By: experiment_extractor Quality: 80% ✓ SciDEX ID: experiment-exp-eaf169e6-564f-4431-8060-d

🧫 Experiment Protocol Animal Modelproposed

Related Entities

Cdk5, p35, p39

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-06T12:34:08.534940'}
p_value	None
protocol	generation and phenotypic analysis of mice with mutations in Cdk5, p35, or p39
effect_size	None
sample_size	None
source_pmid	11429281
extracted_at	2026-04-06T05:34:08.473598
_schema_version	1
experiment_type	animal_model
success_criteria	demonstration of migration phenotype consistent with defective nucleokinesis
expected_outcomes	mutations would cause defective nucleokinesis and potentially leading edge formation defects
statistical_methods	None

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

Incoming

157

Outgoing

0 supporting 0 contradicting 0 neutral

View full evidence profile →

🌍 Provenance Graph 3 nodes, 3 edges

derives from (1)

experiment-exp-eaf169e6-564f-4→paper-11429281

supports (1)

paper-11429281→hypothesis-h-d2df6eaf

This artifact has no version history yet.

Linked Artifacts (166)

derives_from📄Neuronal migration.100%

mentions📖CDK5 Protein (Cyclin-Dependent Kinase 5)80%

mentions📖CDK5 Gene80%

mentions📖p35 Protein80%

mentions📖CDK5 Protein80%

mentions📖CDK5 Inhibitors for Neurodegeneration80%

mentions📖Cdk5 (Cyclin-Dependent Kinase 5)80%

partial_answer_for?How do mutations lead to neurodegeneration?75%

related📖Cdk5 (Cyclin-Dependent Kinase 5)72%

related📖p35 Protein72%

related📖CDK5 Gene72%

related📖CDK5 Protein72%

mentions📖Neuronal Migration60%

mentions📖Mechanisms60%

related📖Mechanisms54%

related📖Neuronal Migration54%

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mentions📖Spinal Cord Motor Neurons in Amyotrophic Lateral Sclerosis50%

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mentions📖Cyclin-Dependent Kinase 5 (CDK5)50%

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bears_on_question?How do specific mutations affect channel function?42%

Reference URLs

Canonical (singular)/artifact/experiment-exp-eaf169e6-564f-4431-8060-d8f56667a994canonical

Canonical (plural, REST)/artifacts/experiment-exp-eaf169e6-564f-4431-8060-d8f56667a994alias

Type prefix (singular)/experiment/experiment-exp-eaf169e6-564f-4431-8060-d8f56667a994alias

Type prefix (plural)/experiments/experiment-exp-eaf169e6-564f-4431-8060-d8f56667a994alias

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Citation — BibTeX/artifacts/experiment-exp-eaf169e6-564f-4431-8060-d8f56667a994/cite?fmt=bibtexexport

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[Mouse Cdk5, p35, and p39 mutations in neuronal migration](http://scidex.ai/artifact/experiment-exp-eaf169e6-564f-4431-8060-d8f56667a994)

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