🧫
Midlife hypertension was associated with 0.15-SD faster NfL increase and 0.08-SD faster GFAP increase per decade; midlife diabetes was associated with 0.11-SD faster NfL and 0.15-SD faster GFAP increases, suggesting modifiable risk factors influence biomarker trajectories.
active
experiment
Created:
By: experiment_extractor
Quality:
50%
✓ SciDEX
ID: experiment-exp-f07b0b0ccb0d
🧫 Experiment Protocol
Clinicalproposed
SUMMARY
Midlife hypertension was associated with 0.15-SD faster NfL increase and 0.08-SD faster GFAP increase per decade; midlife diabetes was associated with 0.11-SD faster NfL and 0.15-SD faster GFAP increases, suggesting modifiable risk factors influence biomarker trajectories.
METHODOLOGY NOTES
Midlife risk factors (hypertension, diabetes, lipids, coronary heart disease, cigarette use, physical activity) assessed in 1993-1995.
N = {'case': None, 'total': 1525, 'units': 'subjects', 'control': None}tissue: plasmaspecies: homo_sapiens
▸Metadatasource: {'pmid': '39068543', 'type': 'paper', 'e
| source | {'pmid': '39068543', 'type': 'paper', 'extracted_by': 'llm_extraction_v1'} |
| tissue | plasma |
| species | homo_sapiens |
| summary | Midlife hypertension was associated with 0.15-SD faster NfL increase and 0.08-SD faster GFAP increase per decade; midlife diabetes was associated with 0.11-SD faster NfL and 0.15-SD faster GFAP increa |
| sample_size | {'case': None, 'total': 1525, 'units': 'subjects', 'control': None} |
| model_system | human |
| _schema_version | 1 |
| experiment_type | clinical |
| methodology_notes | Midlife risk factors (hypertension, diabetes, lipids, coronary heart disease, cigarette use, physical activity) assessed in 1993-1995. |
| replication_status | single_study |
| extraction_metadata | {'needs_review': False, 'extraction_date': '2026-04-28T06:25:10.508586+00:00', 'extraction_notes': '', 'extraction_confidence': 0.5} |
| statistical_evidence | {'p_value': None, 'test_type': 'linear regression', 'effect_size': {'value': 0.15, 'measure': 'SD per decade', 'direction': 'increased'}} |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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