ID: h-3fcd326bc1
Hypothesis
HDAC6 Inhibition for Charcot-Marie-Tooth Disease and ALS
HDAC6 deacetylates α-tubulin and regulates cytoskeletal dynamics.
EvidencePending (0%)📖 0 cit🗣 1 debates✓ 4 support✗ 4 oppose
✓ All Quality Gates Passed
🧪 Overview
HDAC6 deacetylates α-tubulin and regulates cytoskeletal dynamics. HDAC6 overexpression causes axonal transport defects. Selective HDAC6 inhibition restores acetylated tubulin levels, improves axonal transport, and delays disease progression in CMT2A and SOD1 mouse models.
🧬 Mechanism
No curated mechanism pathway recorded for this hypothesis.
⚖️ Evidence
⚖️ Evidence Matrix4 supports4 contradicts
📖 Linked Papers
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — HDAC6
No curated PDB or AlphaFold mapping for HDAC6 yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for HDAC6.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
No arena matches recorded yet. Browse Arenas →
📊 Market Indicators
7d Trend
↘
Falling
7d Momentum
▼ 2.9%
Volatility
Low
0.0028
Events (7d)
4
Price History
▼15.7%💾 Resource Usage
No resource usage or linked notebooks recorded for this hypothesis yet.
Parent Context
▸Metadataorigin_type: debate_synthesizer
| origin_type | debate_synthesizer |
| target_gene | HDAC6 |
| _schema_version | 1 |
| composite_score | 0.793 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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