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Does delta-catenin loss mechanistically contribute to Alzheimer's disease pathogenesis, and if so, what is the nature of its functional interaction with presenilin-1 (PS1) mutations in FAD?

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open question Created: 2026-04-27T23:14:48 By: open_question_miner_papers Quality: 72% 🔗 External ID: open_question-neurodegeneration-cd54c323

Open Question open paper: 15380068

Does delta-catenin loss mechanistically contribute to Alzheimer's disease pathogenesis, and if so, what is the nature of its functional interaction with presenilin-1 (PS1) mutations in FAD?

Importance Elo

1500

Field Rank

Rank #6 in neurodegeneration

Tractability

0.60

Potential Impact

0.85

Evidence Summary

Delta-catenin was first identified through its interaction with Presenilin-1 (PS1), the molecule most frequently mutated in familial Alzheimer's Disease (FAD).

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Related Entities

neurodegeneration

▸Metadata

status	open
_origin	{'url': None, 'type': 'external', 'tracked_at': '2026-04-28T06:14:48.233402'}
field_tag	neurodegeneration
source_id	15380068
source_doi	10.1016/j.cub.2004.08.065
source_kind	paper
question_hash	cd54c3237820232f
question_text	Does delta-catenin loss mechanistically contribute to Alzheimer's disease pathogenesis, and if so, what is the nature of its functional interaction with presenilin-1 (PS1) mutations in FAD?
importance_elo	1500
_schema_version	1
source_paper_id	paper-10_1016_j_cub_2004_08_065
evidence_summary	Delta-catenin was first identified through its interaction with Presenilin-1 (PS1), the molecule most frequently mutated in familial Alzheimer's Disease (FAD).
tractability_score	0.6
potential_impact_score	0.85
is_answerable_in_principle	True

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