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Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.
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ID: paper-30206190
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Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.
["Sousa C", "Golebiewska A", "Poovathingal S", "Kaoma T", "Pires-Afonso Y", "Martina S", "Coowar D", "Azuaje F", "Skupin A", "Balling R"]
Abstract
Microglia are specialized parenchymal-resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural environment. Dysfunctional microglial responses are thought to worsen CNS diseases; nevertheless, their impact during neuroinflammatory processes remains largely obscure. Here, using a combination of single-cell RNA sequencing and multicolour flow cytometry, we comprehensively profile microglia in the brain of lipopolysaccharide (LPS)-injected mice. ...
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