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Testicular Gap (CX43) and Tight Junction (OCLN, CLDN3, 5 and 11) Components in the Dog Are Affected by GnRH-Mediated Downregulation.
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ID: paper-41594443
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Testicular Gap (CX43) and Tight Junction (OCLN, CLDN3, 5 and 11) Components in the Dog Are Affected by GnRH-Mediated Downregulation.
Goericke-Pesch S, Röhrs L, Wallrabenstein S, Frimødt Rønnow A, Fietz D, Brehm R, Langeheine M, Wehrend A, Hoffmann B, Körber H, Packeiser EM
Abstract
Following the downregulation of testicular endocrine and germinative function by slow-release gonadotropin-releasing hormone (GnRH)-agonist implants, testicular functions are quickly restored after implant removal. As an intact blood-testis barrier (BTB) is crucial for normal spermatogenesis and its integrity is FSH- and androgen-dependent, alterations in the BTB gene and protein expressions during downregulation and subsequent restart seem inevitable. We investigated occludin (OCLN), claudin (C...
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📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
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